SB 714786 [Ligand Id: 77] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL425190 (SB-714786)
  • α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
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  • β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
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  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
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  • D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
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  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
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  • 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
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  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
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  • 5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566]
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  • 5-HT1F receptor/Serotonin 1f (5-HT1f) receptor in Human [ChEMBL: CHEMBL1805] [GtoPdb: 5] [UniProtKB: P30939]
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
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  • 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
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  • 5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639]
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  • 5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898]
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  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
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  • 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
ChEMBL Binding affinity for human alpha-1B adrenergic receptor B 6 pKi 1000 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL Binding affinity for human beta-2 adrenergic receptor B 5.7 pKi 1995.26 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Binding affinity for human dopamine receptor D2 B 5.5 pKi 3162.28 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL Binding affinity for human dopamine receptor D3 B 6 pKi 1000 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL Binding affinity for human dopamine receptor D4 B 5 pKi <10000 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Displacement of [3H]WAY-100635 from human 5-hydroxytryptamine 1A receptor expressed in CHO cells B 6.5 pKi 316.23 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
ChEMBL Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor B 6.5 pKi 316.23 nM Ki J Med Chem (2008) 51: 2887-2890 [PMID:18433113]
GtoPdb - - 6.5 pKi - - - J Med Chem (2005) 48: 3478-80 [PMID:15887956]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222]
ChEMBL Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells B 6.7 pKi 199.53 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
ChEMBL Displacement of [3H]5HT from human recombinant 5HT1B receptor B 6.7 pKi 199.53 nM Ki J Med Chem (2008) 51: 2887-2890 [PMID:18433113]
GtoPdb - - 6.7 pKi - - - J Med Chem (2005) 48: 3478-80 [PMID:15887956]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
GtoPdb - - 9.1 pKi 0.79 nM Ki J Med Chem (2005) 48: 3478-80 [PMID:15887956]
ChEMBL Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells B 9.1 pKi 0.79 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
ChEMBL Displacement of [3H]5HT from human recombinant 5HT1D receptor B 9.1 pKi 0.79 nM Ki J Med Chem (2008) 51: 2887-2890 [PMID:18433113]
5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566]
ChEMBL Binding affinity for human 5-hydroxytryptamine 1E receptor B 5 pKi <10000 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
5-HT1F receptor/Serotonin 1f (5-HT1f) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1805] [GtoPdb: 5] [UniProtKB: P30939]
ChEMBL Binding affinity for human 5-hydroxytryptamine 1F receptor B 5.7 pKi 1995.26 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL Binding affinity for human 5-hydroxytryptamine 2A receptor B 5.6 pKi <2511.89 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL Binding affinity for human 5-hydroxytryptamine 2B receptor B 5.9 pKi 1258.93 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL Binding affinity for human 5-hydroxytryptamine 2C receptor B 5.5 pKi 3162.28 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639]
ChEMBL Binding affinity for human 5-hydroxytryptamine 4 receptor B 5.3 pKi <5011.87 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898]
ChEMBL Binding affinity for human 5-hydroxytryptamine 5A receptor B 5.5 pKi 3162.28 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL Binding affinity for human 5-hydroxytryptamine 6 receptor B 5 pKi <10000 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL Binding affinity for human 5-hydroxytryptamine 7 receptor B 6.3 pKi 501.19 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652]
ChEMBL Inhibition of [3H]5-HT binding to serotonin transporter in rat cortical synaptosomes B 6.5 pKi 316.23 nM Ki J Med Chem (2005) 48: 3478-3480 [PMID:15887956]
ChEMBL Inhibition of [3H]5HT uptake at SERT in rat cortical synaptosomes B 6.5 pKi 316.23 nM Ki J Med Chem (2008) 51: 2887-2890 [PMID:18433113]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]