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ChEMBL ligand: CHEMBL425190 (SB-714786) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] | ||||||||
ChEMBL | Binding affinity for human alpha-1B adrenergic receptor | B | 6 | pKi | 1000 | nM | Ki | J Med Chem (2005) 48: 3478-3480 [PMID:15887956] |
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
ChEMBL | Binding affinity for human beta-2 adrenergic receptor | B | 5.7 | pKi | 1995.26 | nM | Ki | J Med Chem (2005) 48: 3478-3480 [PMID:15887956] |
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
ChEMBL | Binding affinity for human dopamine receptor D2 | B | 5.5 | pKi | 3162.28 | nM | Ki | J Med Chem (2005) 48: 3478-3480 [PMID:15887956] |
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] | ||||||||
ChEMBL | Binding affinity for human dopamine receptor D3 | B | 6 | pKi | 1000 | nM | Ki | J Med Chem (2005) 48: 3478-3480 [PMID:15887956] |
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
ChEMBL | Binding affinity for human dopamine receptor D4 | B | 5 | pKi | <10000 | nM | Ki | J Med Chem (2005) 48: 3478-3480 [PMID:15887956] |
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
ChEMBL | Displacement of [3H]WAY-100635 from human 5-hydroxytryptamine 1A receptor expressed in CHO cells | B | 6.5 | pKi | 316.23 | nM | Ki | J Med Chem (2005) 48: 3478-3480 [PMID:15887956] |
ChEMBL | Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor | B | 6.5 | pKi | 316.23 | nM | Ki | J Med Chem (2008) 51: 2887-2890 [PMID:18433113] |
GtoPdb | - | - | 6.5 | pKi | - | - | - | J Med Chem (2005) 48: 3478-80 [PMID:15887956] |
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
ChEMBL | Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells | B | 6.7 | pKi | 199.53 | nM | Ki | J Med Chem (2005) 48: 3478-3480 [PMID:15887956] |
ChEMBL | Displacement of [3H]5HT from human recombinant 5HT1B receptor | B | 6.7 | pKi | 199.53 | nM | Ki | J Med Chem (2008) 51: 2887-2890 [PMID:18433113] |
GtoPdb | - | - | 6.7 | pKi | - | - | - | J Med Chem (2005) 48: 3478-80 [PMID:15887956] |
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
GtoPdb | - | - | 9.1 | pKi | 0.79 | nM | Ki | J Med Chem (2005) 48: 3478-80 [PMID:15887956] |
ChEMBL | Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells | B | 9.1 | pKi | 0.79 | nM | Ki | J Med Chem (2005) 48: 3478-3480 [PMID:15887956] |
ChEMBL | Displacement of [3H]5HT from human recombinant 5HT1D receptor | B | 9.1 | pKi | 0.79 | nM | Ki | J Med Chem (2008) 51: 2887-2890 [PMID:18433113] |
5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566] | ||||||||
ChEMBL | Binding affinity for human 5-hydroxytryptamine 1E receptor | B | 5 | pKi | <10000 | nM | Ki | J Med Chem (2005) 48: 3478-3480 [PMID:15887956] |
5-HT1F receptor/Serotonin 1f (5-HT1f) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1805] [GtoPdb: 5] [UniProtKB: P30939] | ||||||||
ChEMBL | Binding affinity for human 5-hydroxytryptamine 1F receptor | B | 5.7 | pKi | 1995.26 | nM | Ki | J Med Chem (2005) 48: 3478-3480 [PMID:15887956] |
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
ChEMBL | Binding affinity for human 5-hydroxytryptamine 2A receptor | B | 5.6 | pKi | <2511.89 | nM | Ki | J Med Chem (2005) 48: 3478-3480 [PMID:15887956] |
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
ChEMBL | Binding affinity for human 5-hydroxytryptamine 2B receptor | B | 5.9 | pKi | 1258.93 | nM | Ki | J Med Chem (2005) 48: 3478-3480 [PMID:15887956] |
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
ChEMBL | Binding affinity for human 5-hydroxytryptamine 2C receptor | B | 5.5 | pKi | 3162.28 | nM | Ki | J Med Chem (2005) 48: 3478-3480 [PMID:15887956] |
5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639] | ||||||||
ChEMBL | Binding affinity for human 5-hydroxytryptamine 4 receptor | B | 5.3 | pKi | <5011.87 | nM | Ki | J Med Chem (2005) 48: 3478-3480 [PMID:15887956] |
5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898] | ||||||||
ChEMBL | Binding affinity for human 5-hydroxytryptamine 5A receptor | B | 5.5 | pKi | 3162.28 | nM | Ki | J Med Chem (2005) 48: 3478-3480 [PMID:15887956] |
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
ChEMBL | Binding affinity for human 5-hydroxytryptamine 6 receptor | B | 5 | pKi | <10000 | nM | Ki | J Med Chem (2005) 48: 3478-3480 [PMID:15887956] |
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
ChEMBL | Binding affinity for human 5-hydroxytryptamine 7 receptor | B | 6.3 | pKi | 501.19 | nM | Ki | J Med Chem (2005) 48: 3478-3480 [PMID:15887956] |
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] | ||||||||
ChEMBL | Inhibition of [3H]5-HT binding to serotonin transporter in rat cortical synaptosomes | B | 6.5 | pKi | 316.23 | nM | Ki | J Med Chem (2005) 48: 3478-3480 [PMID:15887956] |
ChEMBL | Inhibition of [3H]5HT uptake at SERT in rat cortical synaptosomes | B | 6.5 | pKi | 316.23 | nM | Ki | J Med Chem (2008) 51: 2887-2890 [PMID:18433113] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]