dexmethylphenidate [Ligand Id: 7554] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL827 (Dexmethylphenidate, Methylphenidate d-threo-form)
There should be some charts here, you may need to enable JavaScript!
  • Norepinephrine transporter in Rat [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4]
There should be some charts here, you may need to enable JavaScript!
  • NET in Rat [GtoPdb: 926]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
GtoPdb Displacement of [3H]WIN-35428 from human DAT stably expressed in mouse N2A cells - 7.6 pKi 25 nM Ki Bioorg Med Chem (2011) 19: 504-12 [PMID:21129986]
ChEMBL Displacement of [3H]WIN-35428 from human DAT stably expressed in mouse N2A cells by scintillation countnig B 7.6 pKi 25 nM Ki Bioorg. Med. Chem. (2011) 19: 504-512 [PMID:21129986]
ChEMBL Displacement of [3H]WIN-35,428 from human DAT expressed in mouse N2A cells after 15 mins by liquid scintillation counting B 7.8 pKi 16 nM Ki ACS Med. Chem. Lett. (2012) 3: 378-382 [PMID:23066448]
ChEMBL Inhibition of [3H]dopamine uptake at human DAT expressed in mouse N2A cells B 6.81 pIC50 156 nM IC50 Bioorg. Med. Chem. (2011) 19: 504-512 [PMID:21129986]
ChEMBL Inhibition of [3H]WIN-35428 Binding to the Dopamine Transporter in Rhesus (Macaca mulatta) orCynomolgus Monkey (Macaca fascicularis) Caudate-Putamen B 7.06 pIC50 88 nM IC50 J. Med. Chem. (2003) 46: 1538-1545 [PMID:12672255]
DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977]
ChEMBL Displacement of [3H]WIN 35428 from Sprague-Dawley rat striatal tissue after 2 hrs by liquid scintillation counting B 7.08 pIC50 83.18 nM IC50 Bioorg. Med. Chem. (2010) 18: 7221-7238 [PMID:20846865]
ChEMBL The compound was tested for its affinity at the rat striatal dopamine transporter by the displacement of [3H]WIN-35428 B 7.08 pIC50 83 nM IC50 Bioorg. Med. Chem. Lett. (1997) 7: 1213-1218
ChEMBL Inhibitory potency against dopamine (DA) transporter using [3H]WIN-35428 (WIN-) binding assay. B 7.08 pIC50 83 nM IC50 J. Med. Chem. (1999) 42: 4836-4843 [PMID:10579846]
ChEMBL Displacement of [3H]WIN 35428 from Sprague-Dawley rat striatal tissue after 2 hrs by liquid scintillation counting B 7.08 pIC50 83 nM IC50 Bioorg. Med. Chem. (2010) 18: 7221-7238 [PMID:20846865]
ChEMBL Inhibitory potency against [3H]DA uptake using [3H]WIN-35428 (WIN-) binding assay B 7.62 pIC50 24 nM IC50 J. Med. Chem. (1999) 42: 4836-4843 [PMID:10579846]
Norepinephrine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4]
ChEMBL Selectivity for the norepinephrine transporter using [3H]nisoxetine binding assay B 6 pIC50 989 nM IC50 J. Med. Chem. (1999) 42: 4836-4843 [PMID:10579846]
NET in Rat [GtoPdb: 926]
GtoPdb Displacement of [3H]nisoxetine from NET in Sprague-Dawley rat cortical tissue. - 6.57 pKi 270 nM Ki J Med Chem (2007) 50: 2718-31 [PMID:17489581]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]