BIC1 [Ligand Id: 7510] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1738777 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| bromodomain containing 2/Bromodomain-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293289] [GtoPdb: 1944] [UniProtKB: P25440] | ||||||||
| GtoPdb | Binding to recombinant BRD2-BD1 protein. | - | 4.55 | pKd | 28000 | nM | Kd | Chem Biol (2011) 18: 495-507 [PMID:21513886] |
| ChEMBL | Binding affinity to BRD2-BD1 by SPR spectroscopy | B | 4.55 | pKd | 28000 | nM | Kd | Bioorg Med Chem (2012) 20: 1887-1892 [PMID:22316554] |
| ChEMBL | Binding affinity to BRD2 isoform 1 by SPR | B | 4.55 | pKd | 28000 | nM | Kd | J Med Chem (2012) 55: 9393-9413 [PMID:22924434] |
| ChEMBL | Inhibition of first bromodomain of BRD2 (unknown origin) | B | 4.55 | pIC50 | 28000 | nM | IC50 | J Med Chem (2013) 56: 8073-8088 [PMID:24090311] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
