bufexamac [Ligand Id: 7498] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL94394 (Bufexamac, Bufexamaco, Butoxyphenylacethydroxamic acid, CP 1044 J3, CP-1044-J3, Duradermal, NSC-758153, Parfenac) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Arachidonate 5-lipoxygenase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2980] [UniProtKB: Q9BEG3] | ||||||||
| ChEMBL | 5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leukocytes | F | 4.46 | pIC50 | 35000 | nM | IC50 | J Med Chem (1997) 40: 2780-2787 [PMID:9276024] |
| 5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527] | ||||||||
| ChEMBL | In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1) | B | 4.57 | pIC50 | 27000 | nM | IC50 | J Med Chem (1990) 33: 992-998 [PMID:2308149] |
| ChEMBL | Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1) | B | 6.89 | pIC50 | 128.82 | nM | IC50 | J Med Chem (1990) 33: 992-998 [PMID:2308149] |
| histone deacetylase 10/Histone deacetylase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8] | ||||||||
| GtoPdb | - | - | 4.91 | pKd | 12300 | nM | Kd | Nat Biotechnol (2011) 29: 255-65 [PMID:21258344] |
| ChEMBL | Inhibition of HDAC10 (unknown origin) | B | 4.91 | pKd | 12300 | nM | Kd | J Med Chem (2013) 56: 6297-6313 [PMID:23627282] |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| GtoPdb | - | - | 4.97 | pKd | 10700 | nM | Kd | Nat Biotechnol (2011) 29: 255-65 [PMID:21258344] |
| ChEMBL | Inhibition of HDAC6 (unknown origin) | B | 4.97 | pKd | 10700 | nM | Kd | J Med Chem (2013) 56: 6297-6313 [PMID:23627282] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay | F | 5.56 | pIC50 | 2771 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3597-3604 [PMID:20547797] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
