ChEMBL ligand: CHEMBL94394 (Anderm, Bufexamac, Butoxyphenylacethydroxamic acid, CP 1044 J3, CP-1044-J3, Duradermal, NSC-758153, Paraderm, Parfenac)
Arachidonate 5-lipoxygenase in Bovine [ChEMBL: CHEMBL2980] [UniProtKB: Q9BEG3] 5-LOX/Arachidonate 5-lipoxygenase in Rat [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 10/Histone deacetylase 10 in Human [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Arachidonate 5-lipoxygenase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2980] [UniProtKB: Q9BEG3]
ChEMBL	5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leukocytes	F	4.46	pIC50	35000	nM	IC50	J. Med. Chem. (1997) 40: 2780-2787 [PMID:9276024]
5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
ChEMBL	In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1)	B	4.57	pIC50	27000	nM	IC50	J. Med. Chem. (1990) 33: 992-998 [PMID:2308149]
ChEMBL	Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1)	B	6.89	pIC50	128.82	nM	IC50	J. Med. Chem. (1990) 33: 992-998 [PMID:2308149]
histone deacetylase 10/Histone deacetylase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8]
GtoPdb	-	-	4.91	pKd	12300	nM	Kd	Nat Biotechnol (2011) 29: 255-65 [PMID:21258344]
ChEMBL	Inhibition of HDAC10 (unknown origin)	B	4.91	pKd	12300	nM	Kd	J. Med. Chem. (2013) 56: 6297-6313 [PMID:23627282]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
GtoPdb	-	-	4.97	pKd	10700	nM	Kd	Nat Biotechnol (2011) 29: 255-65 [PMID:21258344]
ChEMBL	Inhibition of HDAC6 (unknown origin)	B	4.97	pKd	10700	nM	Kd	J. Med. Chem. (2013) 56: 6297-6313 [PMID:23627282]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay	F	5.56	pIC50	2771	nM	IC50	Antimicrob. Agents Chemother. (2010) 54: 3597-3604 [PMID:20547797]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]