bufexamac [Ligand Id: 7498] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL94394 (Anderm, Paraderm, Butoxyphenylacethydroxamic acid, CP 1044 J3, Duradermal, Parfenac, Bufexamac)
  • Arachidonate 5-lipoxygenase in Bovine [ChEMBL: CHEMBL2980] [UniProtKB: Q9BEG3]
  • 5-LOX/Arachidonate 5-lipoxygenase in Rat [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
  • This target only has 0 pki data point
  • 0
1 CHEMBL94394_lig_chart_1 Arachidonate 5-lipoxygenase BovineRat
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  • histone deacetylase 10/Histone deacetylase 10 in Human [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8]
  • This target only has 0 pki data point
  • 0
2 CHEMBL94394_lig_chart_2 Histone deacetylase 10 Human
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  • histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
  • This target only has 0 pki data point
  • 0
3 CHEMBL94394_lig_chart_3 Histone deacetylase 6 Human
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  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
  • 0
4 CHEMBL94394_lig_chart_4 Plasmodium falciparum Plasmodium falciparum
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Arachidonate 5-lipoxygenase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2980] [UniProtKB: Q9BEG3]
ChEMBL 5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leukocytes F 4.46 pIC50 35000 nM IC50 J. Med. Chem. (1997) 40: 2780-2787 [PMID:9276024]
5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
ChEMBL In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1) B 4.57 pIC50 27000 nM IC50 J. Med. Chem. (1990) 33: 992-998 [PMID:2308149]
ChEMBL Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1) B 6.89 pIC50 128.82 nM IC50 J. Med. Chem. (1990) 33: 992-998 [PMID:2308149]
histone deacetylase 10/Histone deacetylase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8]
GtoPdb - - 4.91 pKd 12300 nM Kd Nat Biotechnol (2011) 29: 255-65 [PMID:21258344]
ChEMBL Inhibition of HDAC10 (unknown origin) B 4.91 pKd 12300 nM Kd J. Med. Chem. (2013) 56: 6297-6313 [PMID:23627282]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
GtoPdb - - 4.97 pKd 10700 nM Kd Nat Biotechnol (2011) 29: 255-65 [PMID:21258344]
ChEMBL Inhibition of HDAC6 (unknown origin) B 4.97 pKd 10700 nM Kd J. Med. Chem. (2013) 56: 6297-6313 [PMID:23627282]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay F 5.56 pIC50 2771 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3597-3604 [PMID:20547797]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]