ingenol mebutate [Ligand Id: 7443] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1863513 (AGN 204332, Ingenol mebutate, PEP-005, PEP005, Picato) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655] | ||||||||
| GtoPdb | - | - | 9.42 | pKi | 0.38 | nM | Ki | Cancer Res (2004) 64: 3243-55 [PMID:15126366] |
| ChEMBL | Activation of PKCdelta (unknown origin) using phosphatidylserine as substrate | B | 8.39 | pEC50 | 4.1 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 5624-5629 [PMID:23993332] |
| ChEMBL | Activation of PKCdelta (unknown origin) after 40 mins | B | 8.39 | pEC50 | 4.1 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 54-60 [PMID:24332494] |
| protein kinase C alpha in Human [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
| GtoPdb | - | - | 9.52 | pKi | 0.3 | nM | Ki | Cancer Res (2004) 64: 3243-55 [PMID:15126366] |
| protein kinase C beta in Human [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
| GtoPdb | - | - | 9.98 | pKi | 0.1 | nM | Ki | Cancer Res (2004) 64: 3243-55 [PMID:15126366] |
| protein kinase C gamma in Human [GtoPdb: 1484] [UniProtKB: P05129] | ||||||||
| GtoPdb | - | - | 9.79 | pKi | 0.16 | nM | Ki | Cancer Res (2004) 64: 3243-55 [PMID:15126366] |
| protein kinase C epsilon in Human [GtoPdb: 1486] [UniProtKB: Q02156] | ||||||||
| GtoPdb | - | - | 9.77 | pKi | 0.17 | nM | Ki | Cancer Res (2004) 64: 3243-55 [PMID:15126366] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
