tolmetin [Ligand Id: 7311] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1020 (MCN-2559, Tolmetin, Tolectin)
  • aldo-keto reductase family 1 member B/Aldose reductase in Human [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
  • aldo-keto reductase family 1 member B/Aldose reductase in Rat [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943]
  • This target only has 0 pki data point
  • 0
1 CHEMBL1020_lig_chart_1 Aldose reductase HumanRat
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  • COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
  • This target only has 0 pki data point
  • 0
2 CHEMBL1020_lig_chart_2 Cyclooxygenase-1 Human
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3 CHEMBL1020_lig_chart_3 Glyoxalase I Human
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  • Interleukin-8 in Human [ChEMBL: CHEMBL2157] [UniProtKB: P10145]
  • This target only has 0 pki data point
  • 0
4 CHEMBL1020_lig_chart_4 Interleukin-8 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
ChEMBL Inhibition of Homo sapiens (human) aldose reductase B 5.62 pIC50 2390 nM IC50 Med Chem Res (2013) 22: 3589-3605
aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943]
ChEMBL DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) B 5.67 pIC50 2153 nM IC50 DrugMatrix in vitro pharmacology data
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) B 7.39 pIC50 41 nM IC50 DrugMatrix in vitro pharmacology data
Glyoxalase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2424] [UniProtKB: Q04760]
ChEMBL Inhibition of glyoxalase 1 B 4.06 pKi 87800 nM Ki Bioorg. Med. Chem. (2011) 19: 1189-1196 [PMID:21237663]
ChEMBL Inhibition of human glyoxalase 1 B 4.06 pKi 87800 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 4243-4247 [PMID:21689932]
Interleukin-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2157] [UniProtKB: P10145]
ChEMBL Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay B 7.05 pIC50 90 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 4026-4030 [PMID:19560921]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]