ChEMBL ligand: CHEMBL101 (Ambene, Antadol, Artrizin, Azolid, Bizolin, Butacote, Butadion, Butadiona, Butaject, Butapirazol, Butatron, Butazolidin, Butoz, Buzon, Diphebuzol, Diphenylbutazone, Ecobutazone, Elmedal, Equipalazone, Equiphar, Exrheudon n, Fenibutazona, Fenibutol, Fenylbutazon, Flexazone, G-13871, Intrabutazone, Intrazone, Mepha-butazon, NSC-25134, Phebuzine, Phenylbutazone, Phenyzene, Pro-Bute, R-3-ZON, Robizone-v, Shigrodin, Tevcodyne, Uzone, Zolaphen)
COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] There should be some charts here, you may need to enable JavaScript!
Cyclooxygenase-2 in Dog [ChEMBL: CHEMBL4033] [UniProtKB: Q8SPQ9] There should be some charts here, you may need to enable JavaScript!
Nicotinate phosphoribosyltransferase in Human [ChEMBL: CHEMBL4523354] [UniProtKB: Q6XQN6] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Organic anion transporter 3/Solute carrier family 22 member 8 in Human [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7] There should be some charts here, you may need to enable JavaScript!
COX-2 in Human [GtoPdb: 1376] [UniProtKB: P35354] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
GtoPdb	-	-	5.52	pIC50	3000	nM	IC50	Bioorg Med Chem Lett (1996) 6: 707-712
ChEMBL	Compound was evaluated for inhibition of Prostaglandin G/H synthase 1	B	5.52	pIC50	3000	nM	IC50	Bioorg Med Chem Lett (1996) 6: 707-712
Cyclooxygenase-2 in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4033] [UniProtKB: Q8SPQ9]
ChEMBL	Inhibitory activity of the compound against canine COX-2	B	5.42	pIC50	3790	nM	IC50	J Med Chem (2001) 44: 641-659 [PMID:11262075]
Nicotinate phosphoribosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523354] [UniProtKB: Q6XQN6]
ChEMBL	Inhibition of NAPRT (unknown origin)	B	10	pKi	0.1	nM	Ki	WO-2017162840-A1. Sensitization of cancer cells to nampt inhibitors by nicotinic acid phosphoribosyltransferase neutralization (2017)
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
Organic anion transporter 3/Solute carrier family 22 member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
ChEMBL	TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cells	F	4.46	pKi	34700	nM	Ki	J Pharmacol Exp Ther (2002) 302: 666-671 [PMID:12130730]
COX-2 in Human [GtoPdb: 1376] [UniProtKB: P35354]
GtoPdb	-	-	3.55	pIC50	284000	nM	IC50	J Med Chem (1995) 38: 3895-901 [PMID:7562922]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]