calindol [Ligand Id: 719] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1801356 (Calindol)
  • CaS receptor in Human [GtoPdb: 54] [UniProtKB: P41180]
  • CaS receptor/Calcium sensing receptor in Rat [ChEMBL: CHEMBL2516] [GtoPdb: 54] [UniProtKB: P48442]
  • This target only has 0 pki data point
  • 0
1 CHEMBL1801356_lig_chart_1 CaS receptor HumanRat
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  • GPRC6 receptor in Mouse [GtoPdb: 55] [UniProtKB: Q8K4Z6]
  • This target only has 0 pki data point
  • 0
2 CHEMBL1801356_lig_chart_2 GPRC6 receptor Mouse
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CaS receptor in Human [GtoPdb: 54] [UniProtKB: P41180]
GtoPdb - - 6.5 pKd - - - Bioorg Med Chem Lett (2004) 14: 3345-9 [PMID:15149704];
J Biol Chem (2004) 279: 18990-7 [PMID:14976203]
CaS receptor/Calcium sensing receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2516] [GtoPdb: 54] [UniProtKB: P48442]
ChEMBL Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one assay B 6.88 pEC50 132 nM EC50 Bioorg. Med. Chem. (2016) 24: 554-569 [PMID:26752095]
ChEMBL Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one assay B 6.88 pEC50 131.83 nM EC50 Bioorg. Med. Chem. (2016) 24: 554-569 [PMID:26752095]
GPRC6 receptor in Mouse [GtoPdb: 55] [UniProtKB: Q8K4Z6]
GtoPdb This is an inferred IC50 based on 10µM of the compound inhibiting maximum L-ornithine-induced activation of GPCR6 by approximately 50% (see Fig 1B in reference). - 5 pIC50 ~10000 nM IC50 Cell Calcium (2009) 46: 323-32 [PMID:19836834]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]