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ChEMBL ligand: CHEMBL7318 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] | ||||||||
ChEMBL | Compound was evaluated for its binding affinity towards human NET(norepinephrine) transporter | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2000) 43: 1011-1018 [PMID:10715164] |
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
GtoPdb | - | - | 5.8 | pKi | - | - | - | J Med Chem (2000) 43: 1011-8 [PMID:10715164] |
ChEMBL | Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1A receptor | B | 5.83 | pKi | 1470 | nM | Ki | J Med Chem (2000) 43: 1011-1018 [PMID:10715164] |
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
GtoPdb | - | - | 5.2 | pKi | - | - | - | J Med Chem (2000) 43: 1011-8 [PMID:10715164] |
ChEMBL | Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1D receptor | B | 5.21 | pKi | 6225 | nM | Ki | J Med Chem (2000) 43: 1011-1018 [PMID:10715164] |
5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566] | ||||||||
ChEMBL | Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 1E receptor | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2000) 43: 1011-1018 [PMID:10715164] |
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
GtoPdb | - | - | 6.3 | pKi | - | - | - | J Med Chem (2000) 43: 1011-8 [PMID:10715164] |
ChEMBL | Compound was evaluated for its binding affinity towards rat 5-hydroxytryptamine 2A receptor | B | 6.33 | pKi | 470 | nM | Ki | J Med Chem (2000) 43: 1011-1018 [PMID:10715164] |
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909] | ||||||||
ChEMBL | Compound was evaluated for its binding affinity towards rat 5-hydroxytryptamine 2C receptor | B | 6.17 | pKi | 675 | nM | Ki | J Med Chem (2000) 43: 1011-1018 [PMID:10715164] |
GtoPdb | - | - | 6.2 | pKi | - | - | - | J Med Chem (2000) 43: 1011-8 [PMID:10715164] |
5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898] | ||||||||
ChEMBL | Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 5A receptor | B | 5.29 | pKi | 5160 | nM | Ki | J Med Chem (2000) 43: 1011-1018 [PMID:10715164] |
GtoPdb | - | - | 5.3 | pKi | - | - | - | J Med Chem (2000) 43: 1011-8 [PMID:10715164] |
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
ChEMBL | Binding affinity for human 5-hydroxytryptamine 6 receptor expressed in HEK 293 human embryonic kidney cells, [3H]-lysergic acid diethylamide as radioligand | B | 7.27 | pKi | 54 | nM | Ki | J Med Chem (2000) 43: 1011-1018 [PMID:10715164] |
ChEMBL | Binding affinity for human 5-hydroxytryptamine 6 receptor | B | 7.3 | pKi | 50.12 | nM | Ki | J Med Chem (2005) 48: 4216-4219 [PMID:15974573] |
ChEMBL | Binding affinity towards human 5-hydroxytryptamine 6 receptor | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2003) 46: 2795-2812 [PMID:12825922] |
ChEMBL | Binding affinity to 5-HT6 receptor (unknown origin) | B | 7.7 | pKi | 20 | nM | Ki | Med Chem Res (2005) 14: 1-18 |
ChEMBL | Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor transfected in HEK293 cells after 60 mins by liquid scintillation spectrometry | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2015) 58: 7901-7912 [PMID:26099069] |
ChEMBL | Binding affinity against 5 Hydroxy tryptamine 6 receptor | B | 7.7 | pKi | 20 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 1707-1711 [PMID:15745826] |
ChEMBL | Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 6 receptor | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2000) 43: 1011-1018 [PMID:10715164] |
GtoPdb | - | - | 7.7 | pKi | - | - | - | J Med Chem (2000) 43: 1011-8 [PMID:10715164] |
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
GtoPdb | - | - | 6.8 | pKi | - | - | - | J Med Chem (2000) 43: 1011-8 [PMID:10715164] |
ChEMBL | Compound was evaluated for its binding affinity towards human 5-hydroxytryptamine 7 receptor | B | 6.81 | pKi | 155 | nM | Ki | J Med Chem (2000) 43: 1011-1018 [PMID:10715164] |
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] | ||||||||
ChEMBL | Compound was evaluated for its binding affinity towards human serotonin transporter | B | 5.33 | pKi | 4700 | nM | Ki | J Med Chem (2000) 43: 1011-1018 [PMID:10715164] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]