tolbutamide [Ligand Id: 6848] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL782 (1-butyl-3-(p-tolylsulfonyl)urea, Arkozal, Butamide, Diabetamid, Glyconon, Ipoglicone, NSC-23813, NSC-87833, Orinase, Pramidex, Rastinon, Tolbutamida, Tolbutamide, Tolbutamidum, Willbutamide)
  • Organic anion transporter 1/Solute carrier family 22 member 6 in Rat [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956]
Created with Highcharts 10.3.3ValuesChart context menuSolute carrier family 22 member 6pKd RatpKi RatpIC50 RatpEC50 Rat012345Highcharts.com
  • Kir6.2 in Mouse [GtoPdb: 442] [UniProtKB: Q61743]
Created with Highcharts 10.3.3ValuesChart context menuKir6.2pKd MousepKi MousepIC50 MousepEC50 Mouse012345Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Organic anion transporter 1/Solute carrier family 22 member 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956]
ChEMBL Inhibition of rat Oat1 expressed in Xenopus oocytes B 4.26 pKi 55500 nM Ki Bioorg Med Chem (2011) 19: 3320-3340 [PMID:21571536]
ChEMBL TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes F 4.26 pKi 55500 nM Ki Eur J Pharmacol (2000) 398: 193-197 [PMID:10854830]
Kir6.2 in Mouse [GtoPdb: 442] [UniProtKB: Q61743]
GtoPdb - - 4.5 pIC50 - - - Science (1995) 270: 1166-70 [PMID:7502040]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]