ChEMBL ligand: CHEMBL279390 (Lazabemida, Lazabemide, RO-196327, RO 19-6327/000)
Monoamine oxidase A in Human [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397] Monoamine oxidase A in Rat [ChEMBL: CHEMBL3358] [UniProtKB: P21396] There should be some charts here, you may need to enable JavaScript!
Monoamine oxidase B in Human [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338] Monoamine oxidase B in Rat [ChEMBL: CHEMBL2993] [GtoPdb: 2490] [UniProtKB: P19643] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Monoamine oxidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
ChEMBL	Inhibition of MAOA (unknown origin) using kynuramine as substrate preincubated for 30 mins followed by substrate addition	B	4.1	pIC50	>80000	nM	IC50	Medchemcomm (2018) 9: 1871-1881 [PMID:30568755]
Monoamine oxidase A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3358] [UniProtKB: P21396]
ChEMBL	In vitro inhibitory against monoamine oxidase A (MAO-A) in rat brain homogenate.	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (1994) 4: 1195-1198
ChEMBL	In vitro inhibitory activity against rat brain Monoamine oxidase A	B	5	pIC50	>10000	nM	IC50	J Med Chem (1995) 38: 4786-4792 [PMID:7490728]
Monoamine oxidase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338]
ChEMBL	Binding affinity to human recombinant microsomal MAO-B by ITC	B	7.18	pKd	66	nM	Kd	Bioorg Med Chem (2015) 23: 770-778 [PMID:25600407]
ChEMBL	Inhibition constant against human recombinant Monoamine oxidase-B	B	7.08	pKi	84	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4438-4446 [PMID:16137882]
GtoPdb	-	-	7.08	pKi	84	nM	Ki	Adv Neurol (1990) 53: 505-12 [PMID:2122653]; Bioorg Med Chem Lett (2005) 15: 4438-46 [PMID:16137882]
ChEMBL	Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins by MAO-Glo assay	B	7.14	pKi	72.2	nM	Ki	Bioorg Med Chem (2015) 23: 770-778 [PMID:25600407]
ChEMBL	Inhibition of recombinant human MAO-B assessed as reduction in H2O2 production preincubated for 30 mins followed by p-tyramine substrate addition measured after 30 mins by amplex red reagent based fluorescence assay	B	8.22	pKi	6	nM	Ki	Medchemcomm (2018) 9: 1164-1171 [PMID:30109004]
ChEMBL	Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using p-tyramine as substrate incubated for 30 mins by Amplex red reagent based fluorescence analysis	B	8.3	pKi	5	nM	Ki	J Med Chem (2021) 64: 1989-2009 [PMID:33533632]
ChEMBL	Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins by MAO-Glo assay	B	8.41	pKi	3.9	nM	Ki	Bioorg Med Chem (2015) 23: 770-778 [PMID:25600407]
ChEMBL	Inhibition of recombinant human MAO-B using benzylamine as substrate preincubated for 30 mins followed by substrate addition	B	6.92	pIC50	120	nM	IC50	Bioorg Med Chem Lett (2017) 27: 1136-1140 [PMID:28188065]
ChEMBL	Inhibition of human recombinant monoamine oxidase-B assessed as kynuramine conversion to 6-hydroxyquinoline after 20 mins by fluorescence spectrophotometric analysis	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2013) 23: 1269-1273 [PMID:23374869]
ChEMBL	Reversible inhibition of recombinant human MAO-B assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline after 20 mins by fluorescence spectrophotometry	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2013) 23: 5498-5502 [PMID:24012182]
ChEMBL	Inhibition of recombinant human MAO-B using kynuramine as substrate assessed as 4-hydroxyquinoline production after 30 mins by fluorescence spectrophotometry analysis	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2758-2763 [PMID:24794105]
ChEMBL	Inhibition of recombinant human MAO-B expressed in insect cells assessed as inhibition of oxidation of kynuramine to 4-hydroxyquinoline after 20 mins by fluorescence spectrophotometry	B	7.04	pIC50	91	nM	IC50	Eur J Med Chem (2014) 82: 164-171 [PMID:24904963]
ChEMBL	Inhibition of human recombinant MAO-B assessed as kynuramine oxidation to 4-hydroxyquinoline formation by spectrofluorometric analysis	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1206-1211 [PMID:25701250]
ChEMBL	Inhibition of human recombinant MAOB using kynuramine substrate assessed as reduction in MAO-generated 4-hydroxyquinoline level by fluorescence spectrophotometry	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1896-1900 [PMID:25857942]
ChEMBL	Inhibition of human MAO-B expressed in baculovirus infected BT1 cells microsome fraction by fluorescence spectrometry	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2015) 25: 5270-5276 [PMID:26432037]
ChEMBL	Inhibition of recombinant human MAO-B after 20 mins using 50 uM kynuramine as substrate by fluorescence spectrophotometry	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2016) 26: 1200-1204 [PMID:26821818]
ChEMBL	Inhibition of human recombinant MAO-B using kynuramine as substrate incubated for 20 mins by fluorescence spectrophotometric analysis	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2016) 26: 2214-2219 [PMID:27020523]
ChEMBL	Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cell microsomes using kynuramine as substrate after 20 mins by fluorescence spectroscopy	B	7.04	pIC50	91	nM	IC50	Eur J Med Chem (2017) 135: 196-203 [PMID:28456030]
ChEMBL	Inhibition of human recombinant MAO-B expressed in insect cell microsome assessed as 4-hydroxyquinoline formation using kynuramine as substrate after 20 mins by fluorescence spectrophotometry	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem (2012) 20: 7040-7050 [PMID:23122934]
ChEMBL	Inhibition of recombinant human MAO-B using kynuramine as substrate after 20 mins by fluorescence spectrophotometric analysis	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem (2018) 26: 5531-5537 [PMID:30279044]
ChEMBL	Inhibition of human recombinant MAO-B expressed in insect cells microsomes assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate incubated for 20 mins by fluorescence spectrophotometry analysis	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2019) 29: 126677-126677 [PMID:31537422]
ChEMBL	Inhibition of recombinant human MAOB expressed in insect cell microsomes using kynuramine as substrate measured after 20 mins by fluorescence spectrophotometry	B	7.04	pIC50	91	nM	IC50	Bioorg Med Chem Lett (2019) 29: 40-46 [PMID:30455149]
ChEMBL	Inhibition of MAOB (unknown origin) using benzylamine as substrate preincubated for 30 mins followed by substrate addition	B	7.38	pIC50	42	nM	IC50	Medchemcomm (2018) 9: 1871-1881 [PMID:30568755]
ChEMBL	Inhibition of recombinant human MAO-B using benzylamine as substrate incubated for 30 mins by spectrophotometric method	B	7.43	pIC50	37	nM	IC50	Bioorg Med Chem Lett (2018) 28: 2403-2407 [PMID:29925480]
ChEMBL	Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI insect cells using benzylamine as substrate after 30 mins by spectrophotometric analysis	B	7.48	pIC50	33	nM	IC50	Bioorg Med Chem Lett (2019) 29: 839-843 [PMID:30686752]
ChEMBL	Inhibition of human MAO-B	B	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2018) 145: 445-497 [PMID:29335210]
ChEMBL	Inhibition of MAO-B (unknown origin)	B	7.7	pIC50	20	nM	IC50	J Med Chem (2021) 64: 17656-17689 [PMID:34905377]
ChEMBL	Inhibition of human recombinant MAOB using benzylamine as substrate preincubated for 30 mins followed by substrate addition	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2018) 28: 584-588 [PMID:29395970]
ChEMBL	Inhibition of human recombinant soluble MAO-B assessed as thermal shift after 20 mins by SYPRO orange staining-based fluorescence assay	B	5.15	pEC50	7100	nM	EC50	Bioorg Med Chem (2015) 23: 770-778 [PMID:25600407]
Monoamine oxidase B in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2993] [GtoPdb: 2490] [UniProtKB: P19643]
ChEMBL	In vitro inhibitory activity against rat brain Monoamine oxidase B	B	7.52	pIC50	30	nM	IC50	J Med Chem (1995) 38: 4786-4792 [PMID:7490728]
ChEMBL	In vitro inhibitory activity against monoamine oxidase B (MAO-B) in rat brain homogenate.	B	7.66	pIC50	22	nM	IC50	Bioorg Med Chem Lett (1994) 4: 1195-1198

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]