VU0404251 [Ligand Id: 6410] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2151817 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu1 receptor/Metabotropic glutamate receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255] | ||||||||
| ChEMBL | Positive allosteric modulation of mGluR1 | B | 5 | pEC50 | >10000 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 6481-6485 [PMID:22981332] |
| mGlu2 receptor/Metabotropic glutamate receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5137] [GtoPdb: 290] [UniProtKB: Q14416] | ||||||||
| ChEMBL | Positive allosteric modulation of mGluR2 | B | 5 | pEC50 | >10000 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 6481-6485 [PMID:22981332] |
| mGlu3 receptor/Metabotropic glutamate receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2888] [GtoPdb: 291] [UniProtKB: Q14832] | ||||||||
| ChEMBL | Positive allosteric modulation of mGluR3 | B | 5 | pEC50 | >10000 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 6481-6485 [PMID:22981332] |
| mGlu4 receptor/Metabotropic glutamate receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2736] [GtoPdb: 292] [UniProtKB: Q14833] | ||||||||
| ChEMBL | Positive allosteric modulation of mGluR4 | B | 5 | pEC50 | >10000 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 6481-6485 [PMID:22981332] |
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594] | ||||||||
| GtoPdb | - | - | 7.15 | pEC50 | 70 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 6481-5 [PMID:22981332] |
| ChEMBL | Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as calcium mobilization | F | 7.15 | pEC50 | 70 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 6481-6485 [PMID:22981332] |
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
| ChEMBL | Displacement of [3H]methoxyPEPy from rat mGluR5 expressed in human HEK293 cells after 1 hr by scintillation counter | B | 6.82 | pKi | 153 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 6481-6485 [PMID:22981332] |
| GtoPdb | - | - | 8.14 | pEC50 | 7.2 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 6481-5 [PMID:22981332] |
| ChEMBL | Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization | F | 8.14 | pEC50 | 7.24 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 6481-6485 [PMID:22981332] |
| ChEMBL | Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization | F | 8.14 | pEC50 | 7.2 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 6481-6485 [PMID:22981332] |
| mGlu6 receptor/Metabotropic glutamate receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4573] [GtoPdb: 294] [UniProtKB: O15303] | ||||||||
| ChEMBL | Positive allosteric modulation of mGluR6 | B | 5 | pEC50 | >10000 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 6481-6485 [PMID:22981332] |
| mGlu7 receptor/Metabotropic glutamate receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3777] [GtoPdb: 295] [UniProtKB: Q14831] | ||||||||
| ChEMBL | Positive allosteric modulation of mGluR7 | B | 5 | pEC50 | >10000 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 6481-6485 [PMID:22981332] |
| mGlu8 receptor/Metabotropic glutamate receptor 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3228] [GtoPdb: 296] [UniProtKB: O00222] | ||||||||
| ChEMBL | Positive allosteric modulation of mGluR8 | B | 5 | pEC50 | >10000 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 6481-6485 [PMID:22981332] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
