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ChEMBL ligand: CHEMBL53753 (PD-158780) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibition of EGF-dependent autophosphorylation of EGF-R in A431 cells | F | 4.89 | pIC50 | 13000 | nM | IC50 | J Med Chem (1998) 41: 742-751 [PMID:9513602] |
GtoPdb | Inhibition of EGFR autophosphorylation | - | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1997) 40: 1820-6 [PMID:9191958] |
ChEMBL | Tested for inhibition of autophosphorylation in Epidermal growth factor receptor stimulated A431 cells | F | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1997) 40: 1820-1826 [PMID:9191958] |
ChEMBL | Inhibition of Epidermal growth factor receptor autophosphorylation in A431 human epidermoid carcinoma cells | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1996) 39: 1823-1835 [PMID:8627606] |
ChEMBL | Inhibition of autophosphorylation of epidermal growth factor receptor in A431 cells in culture | F | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (1998) 41: 742-751 [PMID:9513602] |
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5] | ||||||||
ChEMBL | Inhibition of MNK1 | B | 5.77 | pIC50 | 1700 | nM | IC50 | J Med Chem (2010) 53: 6618-6628 [PMID:20722422] |
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] | ||||||||
ChEMBL | Inhibition of heregulin-dependent autophosphorylation of ErbB2 receptor in MDA-MB-453 cells | F | 4.28 | pIC50 | 52000 | nM | IC50 | J Med Chem (1998) 41: 742-751 [PMID:9513602] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]