ChEMBL ligand: CHEMBL53753 (PD-158780)
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5] There should be some charts here, you may need to enable JavaScript!
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL	Inhibition of EGF-dependent autophosphorylation of EGF-R in A431 cells	F	4.89	pIC50	13000	nM	IC50	J. Med. Chem. (1998) 41: 742-751 [PMID:9513602]
GtoPdb	Inhibition of EGFR autophosphorylation	-	7.82	pIC50	15	nM	IC50	J Med Chem (1997) 40: 1820-6 [PMID:9191958]
ChEMBL	Tested for inhibition of autophosphorylation in Epidermal growth factor receptor stimulated A431 cells	F	7.82	pIC50	15	nM	IC50	J. Med. Chem. (1997) 40: 1820-1826 [PMID:9191958]
ChEMBL	Inhibition of Epidermal growth factor receptor autophosphorylation in A431 human epidermoid carcinoma cells	B	7.82	pIC50	15	nM	IC50	J. Med. Chem. (1996) 39: 1823-1835 [PMID:8627606]
ChEMBL	Inhibition of autophosphorylation of epidermal growth factor receptor in A431 cells in culture	F	7.89	pIC50	13	nM	IC50	J. Med. Chem. (1998) 41: 742-751 [PMID:9513602]
MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5]
ChEMBL	Inhibition of MNK1	B	5.77	pIC50	1700	nM	IC50	J. Med. Chem. (2010) 53: 6618-6628 [PMID:20722422]
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
ChEMBL	Inhibition of heregulin-dependent autophosphorylation of ErbB2 receptor in MDA-MB-453 cells	F	4.28	pIC50	52000	nM	IC50	J. Med. Chem. (1998) 41: 742-751 [PMID:9513602]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]