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ChEMBL ligand: CHEMBL257167 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] | ||||||||
ChEMBL | Inhibition of IKK-beta | B | 7.7 | pIC50 | 19.95 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2255-2258 [PMID:21429745] |
ChEMBL | Inhibition of IKK-beta | B | 7.71 | pIC50 | 19.5 | nM | IC50 | J Med Chem (2008) 51: 7898-7914 [PMID:19035792] |
ChEMBL | Inhibition of IKK beta at 300 uM by K-ELISA | B | 7.74 | pIC50 | 18 | nM | IC50 | J Nat Prod (2008) 71: 106-111 [PMID:18088098] |
ChEMBL | Inhibition of IKK-beta by TR-FRET assay | B | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem (2009) 17: 2759-2766 [PMID:19285872] |
GtoPdb | FRET measurement using recombinant human IKK2 (residues 1-756) | - | 7.75 | pIC50 | 17.9 | nM | IC50 | J Pharmacol Exp Ther (2005) 312: 373-81 [PMID:15316093] |
eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525] | ||||||||
ChEMBL | Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay | B | 6.6 | pIC50 | 250 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4108-4114 [PMID:21632247] |
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
ChEMBL | Binding affinity to human JAK2 | B | 7.66 | pKd | 22 | nM | Kd | J Med Chem (2008) 51: 7898-7914 [PMID:19035792] |
ChEMBL | Inhibition of JAK2 | B | 8.3 | pKi | 5 | nM | Ki | J Med Chem (2008) 51: 7898-7914 [PMID:19035792] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]