ChEMBL ligand: CHEMBL535
large tumor suppressor kinase 1 in Human [GtoPdb: 1515] [UniProtKB: O95835] There should be some charts here, you may need to enable JavaScript!
large tumor suppressor kinase 2 in Human [GtoPdb: 1516] [UniProtKB: Q9NRM7] There should be some charts here, you may need to enable JavaScript!
platelet derived growth factor receptor beta in Human [GtoPdb: 1804] [UniProtKB: P09619] There should be some charts here, you may need to enable JavaScript!
KIT proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1805] [UniProtKB: P10721] There should be some charts here, you may need to enable JavaScript!
fms related receptor tyrosine kinase 3 in Human [GtoPdb: 1807] [UniProtKB: P36888] There should be some charts here, you may need to enable JavaScript!
fibroblast growth factor receptor 1 in Human [GtoPdb: 1808] [UniProtKB: P11362] There should be some charts here, you may need to enable JavaScript!
kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968] There should be some charts here, you may need to enable JavaScript!
fms related receptor tyrosine kinase 4 in Human [GtoPdb: 1814] [UniProtKB: P35916] There should be some charts here, you may need to enable JavaScript!
ret proto-oncogene in Human [GtoPdb: 2185] [UniProtKB: P07949] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
large tumor suppressor kinase 1 in Human [GtoPdb: 1515] [UniProtKB: O95835]
GtoPdb	-	-	6.2	pKd	630	nM	Kd
large tumor suppressor kinase 2 in Human [GtoPdb: 1516] [UniProtKB: Q9NRM7]
GtoPdb	-	-	6.34	pKd	460	nM	Kd	Blood (2009) 114: 2984-92 [PMID:19654408]
platelet derived growth factor receptor beta in Human [GtoPdb: 1804] [UniProtKB: P09619]
GtoPdb	-	-	8.1	pKi	8	nM	Ki	Clin Cancer Res (2003) 9: 327-37 [PMID:12538485]
GtoPdb	-	-	8.2	pIC50	5.7	nM	IC50	Genes Cells (2013) 18: 110-22 [PMID:23279183]
KIT proto-oncogene, receptor tyrosine kinase in Human [GtoPdb: 1805] [UniProtKB: P10721]
GtoPdb	-	-	9.43	pKd	0.37	nM	Kd	Nat Biotechnol (2011) 29: 1046-51 [PMID:22037378]
GtoPdb	-	-	7.88	pIC50	13.1	nM	IC50	Bioorg Med Chem (2010) 18: 4674-86 [PMID:20570526]
fms related receptor tyrosine kinase 3 in Human [GtoPdb: 1807] [UniProtKB: P36888]
GtoPdb	-	-	8.19	pIC50	6.5	nM	IC50	Bioorg Med Chem (2010) 18: 4674-86 [PMID:20570526]
fibroblast growth factor receptor 1 in Human [GtoPdb: 1808] [UniProtKB: P11362]
GtoPdb	-	-	6.08	pKi	830	nM	Ki	Clin Cancer Res (2003) 9: 327-37 [PMID:12538485]
kinase insert domain receptor in Human [GtoPdb: 1813] [UniProtKB: P35968]
GtoPdb	-	-	7.65	pIC50	22.6	nM	IC50	Bioorg Med Chem (2010) 18: 4674-86 [PMID:20570526]
fms related receptor tyrosine kinase 4 in Human [GtoPdb: 1814] [UniProtKB: P35916]
GtoPdb	-	-	8.05	pIC50	8.9	nM	IC50	Bioorg Med Chem (2010) 18: 4674-86 [PMID:20570526]
ret proto-oncogene in Human [GtoPdb: 2185] [UniProtKB: P07949]
GtoPdb	-	-	8.8	pIC50	1.7	nM	IC50	Genes Cells (2013) 18: 110-22 [PMID:23279183]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]