prenalterol [Ligand Id: 537] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1160714 (Phenol metabolite, Prenalterol)
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  • β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta-2 adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3373] [UniProtKB: Q28044]
ChEMBL Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA) B 5.97 pKd 1072 nM Kd J Med Chem (1985) 28: 1328-1334 [PMID:2993621]
ChEMBL Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA) B 6.27 pKd 6.27 - -Log KD J Med Chem (1985) 28: 1328-1334 [PMID:2993621]
β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588]
GtoPdb - - 6.6 pKi - - - Mol Pharmacol (1999) 56: 875-85 [PMID:10531390];
Mol Pharmacol (1989) 35: 295-303 [PMID:2564629]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]