prenalterol [Ligand Id: 537] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1160714 (Prenalterol, Phenol metabolite)
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  • β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta-2 adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3373] [UniProtKB: Q28044]
ChEMBL Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA) B 5.97 pKd 1072 nM Kd J. Med. Chem. (1985) 28: 1328-1334 [PMID:2993621]
ChEMBL Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA) B 6.27 pKd 6.27 - -Log KD J. Med. Chem. (1985) 28: 1328-1334 [PMID:2993621]
β1-adrenoceptor in Human [GtoPdb: 28] [UniProtKB: P08588]
GtoPdb - - 6.6 pKi - - - Mol Pharmacol (1999) 56: 875-85 [PMID:10531390];
Mol Pharmacol (1989) 35: 295-303 [PMID:2564629]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]