NIL [Ligand Id: 5231] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL340800
  • Neuronal NOS/Nitric-oxide synthase, brain in Human [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475]
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  • Endothelial NOS/Nitric-oxide synthase, endothelial in Human [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474]
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  • Inducible NOS/Nitric oxide synthase, inducible in Human [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475]
ChEMBL Inhibition of human neuronal Nitric Oxide Synthase B 4.43 pIC50 37000 nM IC50 Bioorg. Med. Chem. Lett. (2000) 10: 597-600 [PMID:10741561]
Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474]
ChEMBL Inhibition of human endothelial Nitric Oxide Synthase B 4.11 pIC50 78000 nM IC50 Bioorg. Med. Chem. Lett. (2000) 10: 597-600 [PMID:10741561]
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228]
GtoPdb - - 5.5 pIC50 3160 nM IC50 J. Med. Chem. (1994) 37: 3886-8 [PMID:7525961]
ChEMBL Inhibition of human inducible nitric oxide synthase B 5.8 pIC50 1600 nM IC50 Bioorg. Med. Chem. Lett. (2000) 10: 597-600 [PMID:10741561]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]