CGP53353 [Ligand Id: 5163] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL7939 (CGP-53353)
  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
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  • platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor in Mouse [ChEMBL: CHEMBL2096980] [GtoPdb: 18041803] [UniProtKB: P05622P26618]
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  • SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
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  • protein kinase C beta in Human [GtoPdb: 1483] [UniProtKB: P05771]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Inhibition of EGF-dependent autophosphorylation of EGF-R in human A431 cells F 5.66 pIC50 2200 nM IC50 J. Med. Chem. (1994) 37: 1015-1027 [PMID:8151612]
ChEMBL Inhibitory activity against recombinant tyrosine kinase EGF-R (EGF-R ICD) B 6.15 pIC50 700 nM IC50 J. Med. Chem. (1994) 37: 1015-1027 [PMID:8151612]
platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor in Mouse (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096980] [GtoPdb: 18041803] [UniProtKB: P05622P26618]
ChEMBL Inhibition of PDGF-dependent autophosphorylation of PDGF-R in mouse BALB/c3T3 cells F 4 pIC50 100000 nM IC50 J. Med. Chem. (1994) 37: 1015-1027 [PMID:8151612]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL Inhibitory activity against c-src tyrosine kinase B 4.3 pIC50 50000 nM IC50 J. Med. Chem. (1994) 37: 1015-1027 [PMID:8151612]
protein kinase C beta in Human [GtoPdb: 1483] [UniProtKB: P05771]
GtoPdb - - 6.4 pIC50 398 nM IC50 Mol Endocrinol (1996) 10: 1273-81 [PMID:9121494]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]