CDC [Ligand Id: 5162] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL37141
  • 15-LOX-1/Arachidonate 12-lipoxygenase in Rat [ChEMBL: CHEMBL2741] [GtoPdb: 1388] [UniProtKB: Q02759]
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  • 15-LOX-2/Arachidonate 15-lipoxygenase, type II in Rat [ChEMBL: CHEMBL3289] [GtoPdb: 1389] [UniProtKB: Q8K4F2]
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  • 5-LOX/Arachidonate 5-lipoxygenase in Rat [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
15-LOX-1/Arachidonate 12-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2741] [GtoPdb: 1388] [UniProtKB: Q02759]
ChEMBL Inhibitory activity against 12-lipoxygenase in rat platelet rich plasma B 7.2 pIC50 63 nM IC50 J Med Chem (1991) 34: 1503-1505 [PMID:2016727]
15-LOX-2/Arachidonate 15-lipoxygenase, type II in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3289] [GtoPdb: 1389] [UniProtKB: Q8K4F2]
ChEMBL Inhibitory activity against 15-lipoxygenase in rat polymorphonuclear leukocytes B 5.48 pIC50 3330 nM IC50 J Med Chem (1991) 34: 1503-1505 [PMID:2016727]
5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
ChEMBL Inhibitory activity against 5-lipoxygenase in rat polymorphonuclear leukocytes B 5.72 pIC50 1890 nM IC50 J Med Chem (1991) 34: 1503-1505 [PMID:2016727]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]