bestatin [Ligand Id: 5151] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL476869
  • Leukotriene A4 hydrolase in Human [GtoPdb: 1395] [UniProtKB: P09960]
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  • Leucine aminopeptidase 3 in Bovine [GtoPdb: 1569]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Leukotriene A4 hydrolase in Human [GtoPdb: 1395] [UniProtKB: P09960]
GtoPdb Inhibition of LTB4 formation by isolated human enzyme in vitro. - 5.4 pKi 4000 nM Ki J Biol Chem (1991) 266: 1375-8 [PMID:1846352]
Leucine aminopeptidase 3 in Bovine [GtoPdb: 1569]
GtoPdb - - 9.22 pKi 0.6 nM Ki Biochemistry (1993) 32: 784-90 [PMID:8422382];
J Med Chem (2003) 46: 2641-55 [PMID:12801228]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]