ChEMBL ligand: CHEMBL89598 (5-hexenoic acid, 4-amino-, CPP-109, Gamma vinyl gaba, Gamma-vinyl gaba, Kigabeq, MDL 71,754, MDL-71754, RMI-71754, Sabril, Vigabatrin, Vigabatrina, Vigabatrine, Vinyl gamma-aminobutyric acid)
4-aminobutyrate aminotransferase in Human [GtoPdb: 2464] [UniProtKB: P80404] 4-aminobutyrate aminotransferase/4-aminobutyrate aminotransferase, mitochondrial in Mouse [ChEMBL: CHEMBL4523258] [GtoPdb: 2464] [UniProtKB: P61922] There should be some charts here, you may need to enable JavaScript!
4-aminobutyrate aminotransferase in Human [GtoPdb: 2464] [UniProtKB: P80404] 4-aminobutyrate aminotransferase/Gamma-amino-N-butyrate transaminase in Rat [ChEMBL: CHEMBL3148] [GtoPdb: 2464] [UniProtKB: P50554] There should be some charts here, you may need to enable JavaScript!
Vesicular inhibitory amino acid transporter in Human [GtoPdb: 1133] [UniProtKB: Q9H598] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
4-aminobutyrate aminotransferase in Human [GtoPdb: 2464] [UniProtKB: P80404]
GtoPdb	-	-	3.07	pKi	850000	nM	Ki	Eur J Biochem (1977) 74: 441-5 [PMID:856582]; J Med Chem (2012) 55: 567-75 [PMID:22168767]
4-aminobutyrate aminotransferase/4-aminobutyrate aminotransferase, mitochondrial in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523258] [GtoPdb: 2464] [UniProtKB: P61922]
ChEMBL	Inhibition of GABA aminotransferase in mouse brain homogenates using GABA and alpha-ketoglutarate as substrates preincubated for 30 mins followed by beta-NADP addition and measured for 20 mins by spectrophotometric method	B	4.4	pIC50	39720	nM	IC50	Bioorg Med Chem Lett (2019) 29: 1825-1830 [PMID:31084949]
4-aminobutyrate aminotransferase in Human [GtoPdb: 2464] [UniProtKB: P80404]
GtoPdb	-	-	3.07	pKi	850000	nM	Ki	Eur J Biochem (1977) 74: 441-5 [PMID:856582]; J Med Chem (2012) 55: 567-75 [PMID:22168767]
4-aminobutyrate aminotransferase/Gamma-amino-N-butyrate transaminase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3148] [GtoPdb: 2464] [UniProtKB: P50554]
ChEMBL	Inhibition of Rattus norvegicus (rat) brain gamma-amino butyrate aminotransferase using gamma-amino butyrate as substrate assessed as decrease in NADPH generation after 30 min by spectrophotometric analysis	B	4.38	pIC50	41210	nM	IC50	Med Chem Res (2013) 22: 134-146
Vesicular inhibitory amino acid transporter in Human [GtoPdb: 1133] [UniProtKB: Q9H598]
GtoPdb	-	-	2.1	pIC50	7500000	nM	IC50	Nature (1997) 389: 870-6 [PMID:9349821]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]