penicillin G [Ligand Id: 4796] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL29 (Benzyl penicillin, Benzylpenicillin, Benzylpenicillin, Bicillin, Crystapen g, J01CE01, NSC-193396, Penicillin-2, Penicillin g, Penicillin G, Permapen, Pfizerpen-AS)
  • Beta-lactamase TEM in Escherichia coli [ChEMBL: CHEMBL2065] [UniProtKB: P62593]
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  • Organic anion transporter 3/Solute carrier family 22 member 8 in Human [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
  • Organic anion transporter 3/Solute carrier family 22 member 8 in Rat [ChEMBL: CHEMBL2073666] [GtoPdb: 1027] [UniProtKB: Q9R1U7]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta-lactamase TEM in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2065] [UniProtKB: P62593]
ChEMBL Inhibition constant (Ki) for TEM-1 beta-lactamase B 4.7 pKi 20000 nM Ki J Med Chem (1988) 31: 370-374 [PMID:3257523]
Organic anion transporter 3/Solute carrier family 22 member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7]
ChEMBL TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cells F 4.01 pKi 97600 nM Ki J Pharmacol Exp Ther (2002) 302: 666-671 [PMID:12130730]
Organic anion transporter 3/Solute carrier family 22 member 8 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073666] [GtoPdb: 1027] [UniProtKB: Q9R1U7]
ChEMBL TP_TRANSPORTER: inhibition of Pravastatin uptake in Oat3-expressing LLC-PK1 cells F 4.28 pKi 52800 nM Ki J Pharmacol Exp Ther (2002) 300: 746-753 [PMID:11861777]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]