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ChEMBL ligand: CHEMBL1424 (Xanthine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
ChEMBL | Inhibition of human AChE using acetylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method | B | 5.05 | pIC50 | 9000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4336-4341 [PMID:23791077] |
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
ChEMBL | Relaxant activity on the spontaneous tone of isolated guinea pig tracheal ring chains. | F | 4 | pEC50 | >100000 | nM | EC50 | J Med Chem (1992) 35: 4039-4044 [PMID:1331453] |
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
ChEMBL | Inhibition of human BuChE using S-butyrylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4336-4341 [PMID:23791077] |
Guanine deaminase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3129] [UniProtKB: Q9Y2T3] | ||||||||
ChEMBL | Inhibition of GDA by colorimetric assay | B | 5.71 | pKi | 1960 | nM | Ki | Bioorg Med Chem (2010) 18: 6748-6755 [PMID:20716488] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]