hemicholinium-3 [Ligand Id: 4494] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL268697 (hemicholinium-3, HC-3)
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  • CHT in Human [GtoPdb: 914] [UniProtKB: Q9GZV3]
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  • Choline transporter-like 1 in Human [GtoPdb: 1204] [UniProtKB: Q8WWI5]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum Dd2 infected in human erythrocytes after 48 hrs by picogreen-microfluorimetric assay F 4.3 pIC50 >50000 nM IC50 Bioorg Med Chem Lett (2018) 28: 2485-2489 [PMID:29880399]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR green 1-based fluorimetric assay F 4.3 pIC50 >50000 nM IC50 Bioorg Med Chem Lett (2018) 28: 2485-2489 [PMID:29880399]
CHT in Human [GtoPdb: 914] [UniProtKB: Q9GZV3]
GtoPdb - - 8 pKi 10 nM Ki Neurochem. Res. (2003) 28: 483-8 [PMID:12675135]
Choline transporter-like 1 in Human [GtoPdb: 1204] [UniProtKB: Q8WWI5]
GtoPdb - - 4.5 pKi 31000 nM Ki

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]