isradipine [Ligand Id: 4488] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1648 (Dynacirc, Dynacirc cr, Isradipine, Isradipino, Isrodipine, NSC-759892, PN 200-110, PN-200-110, Prescal) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936] | ||||||||
| GtoPdb | - | - | 8.5 | pIC50 | - | - | - | J Neurosci (2017) 37: 6761-6777 [PMID:28592699] |
| ChEMBL | Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit | F | 8.66 | pIC50 | 2.2 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
| GtoPdb | - | - | 8.8 | pIC50 | - | - | - | J Neurosci (2017) 37: 6761-6777 [PMID:28592699] |
| Voltage-gated L-type calcium channel alpha-1C subunit in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2830] [UniProtKB: P15381] | ||||||||
| ChEMBL | Antagonist activity at rabbit voltage-dependent L-type calcium channel Cav1.2alpha-1C expressed in HEK293 cells by FLIPR assay | B | 6.97 | pIC50 | 107 | nM | IC50 | Bioorg Med Chem (2013) 21: 4365-4373 [PMID:23688558] |
| Cav1.2 in Mouse [GtoPdb: 529] [UniProtKB: Q01815] | ||||||||
| GtoPdb | - | - | 7.5 | pIC50 | - | - | - | J Clin Invest (2004) 113: 1430-9 [PMID:15146240] |
| Cav1.3 in Human [GtoPdb: 530] [UniProtKB: Q01668] | ||||||||
| GtoPdb | - | - | 8.2 | pIC50 | - | - | - | J Neurosci (2017) 37: 6761-6777 [PMID:28592699] |
| GtoPdb | Recombinant Cav1.3 calcium channel complexes expressed in tsA201-cells | - | 9.3 | pIC50 | 0.51 | nM | IC50 | Mol Pharmacol (2009) 75: 407-14 [PMID:19029287] |
| Cav1.3/Voltage-gated L-type calcium channel alpha-1D subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4132] [GtoPdb: 530] [UniProtKB: P27732] | ||||||||
| ChEMBL | Antagonist activity at rat voltage-dependent L-type calcium channel Cav1.3alpha-1D expressed in HEK293 cells by FLIPR assay | B | 6.66 | pIC50 | 221 | nM | IC50 | Bioorg Med Chem (2013) 21: 4365-4373 [PMID:23688558] |
| Cav1.4 in Mouse [GtoPdb: 531] [UniProtKB: Q9JIS7] | ||||||||
| GtoPdb | - | - | 6.7 | pIC50 | - | - | - | Invest Ophthalmol Vis Sci (2004) 45: 708-13 [PMID:14744918] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
