isradipine [Ligand Id: 4488] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1648 (PN-200-110, Dynacirc cr, Prescal, Isrodipine, Dynacirc, Isradipine, PN 200-110)
  • Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936]
  • Voltage-gated L-type calcium channel alpha-1C subunit in Rabbit [ChEMBL: CHEMBL2830] [UniProtKB: P15381]
  • Cav1.2 in Mouse [GtoPdb: 529] [UniProtKB: Q01815]
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  • Cav1.3 in Human [GtoPdb: 530] [UniProtKB: Q01668]
  • Cav1.3/Voltage-gated L-type calcium channel alpha-1D subunit in Rat [ChEMBL: CHEMBL4132] [GtoPdb: 530] [UniProtKB: P27732]
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  • Cav1.4 in Mouse [GtoPdb: 531] [UniProtKB: Q9JIS7]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936]
GtoPdb - - 8.5 pIC50 - - - J Neurosci (2017) 37: 6761-6777 [PMID:28592699]
ChEMBL Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit F 8.66 pIC50 2.2 nM IC50 Journal of Applied Toxicology (2012) 32: 858-866 [PMID:22761000]
GtoPdb - - 8.8 pIC50 - - - J Neurosci (2017) 37: 6761-6777 [PMID:28592699]
Voltage-gated L-type calcium channel alpha-1C subunit in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2830] [UniProtKB: P15381]
ChEMBL Antagonist activity at rabbit voltage-dependent L-type calcium channel Cav1.2alpha-1C expressed in HEK293 cells by FLIPR assay B 6.97 pIC50 107 nM IC50 Bioorg. Med. Chem. (2013) 21: 4365-4373 [PMID:23688558]
Cav1.2 in Mouse [GtoPdb: 529] [UniProtKB: Q01815]
GtoPdb - - 7.5 pIC50 - - - J Clin Invest (2004) 113: 1430-9 [PMID:15146240]
Cav1.3 in Human [GtoPdb: 530] [UniProtKB: Q01668]
GtoPdb - - 8.2 pIC50 - - - J Neurosci (2017) 37: 6761-6777 [PMID:28592699]
GtoPdb Recombinant Cav1.3 calcium channel complexes expressed in tsA201-cells - 9.3 pIC50 0.51 nM IC50 Mol Pharmacol (2009) 75: 407-14 [PMID:19029287]
Cav1.3/Voltage-gated L-type calcium channel alpha-1D subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4132] [GtoPdb: 530] [UniProtKB: P27732]
ChEMBL Antagonist activity at rat voltage-dependent L-type calcium channel Cav1.3alpha-1D expressed in HEK293 cells by FLIPR assay B 6.66 pIC50 221 nM IC50 Bioorg. Med. Chem. (2013) 21: 4365-4373 [PMID:23688558]
Cav1.4 in Mouse [GtoPdb: 531] [UniProtKB: Q9JIS7]
GtoPdb - - 6.7 pIC50 - - - Invest Ophthalmol Vis Sci (2004) 45: 708-13 [PMID:14744918]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]