isradipine [Ligand Id: 4488] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1648 (Dynacirc, Dynacirc cr, Isradipine, Isrodipine, NSC-759892, PN 200-110, PN-200-110, Prescal) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936] | ||||||||
| GtoPdb | - | - | 8.5 | pIC50 | - | - | - | J Neurosci (2017) 37: 6761-6777 [PMID:28592699] |
| ChEMBL | Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit | F | 8.66 | pIC50 | 2.2 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
| GtoPdb | - | - | 8.8 | pIC50 | - | - | - | J Neurosci (2017) 37: 6761-6777 [PMID:28592699] |
| Voltage-gated L-type calcium channel alpha-1C subunit in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2830] [UniProtKB: P15381] | ||||||||
| ChEMBL | Antagonist activity at rabbit voltage-dependent L-type calcium channel Cav1.2alpha-1C expressed in HEK293 cells by FLIPR assay | B | 6.97 | pIC50 | 107 | nM | IC50 | Bioorg Med Chem (2013) 21: 4365-4373 [PMID:23688558] |
| Cav1.2 in Mouse [GtoPdb: 529] [UniProtKB: Q01815] | ||||||||
| GtoPdb | - | - | 7.5 | pIC50 | - | - | - | J Clin Invest (2004) 113: 1430-9 [PMID:15146240] |
| Cav1.3 in Human [GtoPdb: 530] [UniProtKB: Q01668] | ||||||||
| GtoPdb | - | - | 8.2 | pIC50 | - | - | - | J Neurosci (2017) 37: 6761-6777 [PMID:28592699] |
| GtoPdb | Recombinant Cav1.3 calcium channel complexes expressed in tsA201-cells | - | 9.3 | pIC50 | 0.51 | nM | IC50 | Mol Pharmacol (2009) 75: 407-14 [PMID:19029287] |
| Cav1.3/Voltage-gated L-type calcium channel alpha-1D subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4132] [GtoPdb: 530] [UniProtKB: P27732] | ||||||||
| ChEMBL | Antagonist activity at rat voltage-dependent L-type calcium channel Cav1.3alpha-1D expressed in HEK293 cells by FLIPR assay | B | 6.66 | pIC50 | 221 | nM | IC50 | Bioorg Med Chem (2013) 21: 4365-4373 [PMID:23688558] |
| Cav1.4 in Mouse [GtoPdb: 531] [UniProtKB: Q9JIS7] | ||||||||
| GtoPdb | - | - | 6.7 | pIC50 | - | - | - | Invest Ophthalmol Vis Sci (2004) 45: 708-13 [PMID:14744918] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
