ChEMBL ligand: CHEMBL410873
A1 receptor in Human [GtoPdb: 18] [UniProtKB: P30542] A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] There should be some charts here, you may need to enable JavaScript!
A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274] A2A receptor/Adenosine A2a receptor in Rat [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] There should be some charts here, you may need to enable JavaScript!
A3 receptor in Human [GtoPdb: 21] [UniProtKB: P0DMS8] A3 receptor/Adenosine A3 receptor in Rat [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] There should be some charts here, you may need to enable JavaScript!
A2B receptor in Human [GtoPdb: 20] [UniProtKB: P29275] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
A1 receptor in Human [GtoPdb: 18] [UniProtKB: P30542]
GtoPdb	-	-	7.2	pKi	-	-	-	J Med Chem (2002) 45: 3271-9 [PMID:12109910]
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL	Binding affinity against low affinity component of adenosine A1 receptors from rat brain membranes using [3H]-DPCPX	B	5.5	pKi	3160	nM	Ki	J Med Chem (1992) 35: 2363-2368 [PMID:1619615]
ChEMBL	Binding affinity against adenosine A1 receptor from rat brain membranes using [3H]cyclohexyladenosine as radioligand.	B	6.56	pKi	276	nM	Ki	J Med Chem (1992) 35: 2881-2890 [PMID:1495019]
ChEMBL	Binding affinity against high affinity component of adenosine A1 receptors from rat brain membranes using [3H]DPCPX	B	6.87	pKi	136	nM	Ki	J Med Chem (1992) 35: 2363-2368 [PMID:1619615]
ChEMBL	Displacement of [3H]CHA from Adenosine A1 receptor of rat brain	B	6.89	pKi	130	nM	Ki	J Med Chem (1996) 39: 4211-4217 [PMID:8863798]
ChEMBL	Binding affinity against adenosine A1 receptor from rat brain using [3H]CHA as a radioligand.	B	6.89	pKi	130	nM	Ki	J Med Chem (1995) 38: 1462-1472 [PMID:7739005]
ChEMBL	Affinity for adenosine A1 receptor assayed in a competition assay in rat brain using [3H]-CHA as radioligand	B	6.89	pKi	130	nM	Ki	J Med Chem (1994) 37: 1720-1726 [PMID:8201607]
ChEMBL	Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand.	B	6.89	pKi	130	nM	Ki	J Med Chem (1995) 38: 1174-1188 [PMID:7707320]
ChEMBL	Binding affinity against adenosine A1 receptors from rat brain membranes using [3H]CCPA	B	7.36	pKi	43.9	nM	Ki	J Med Chem (1992) 35: 2363-2368 [PMID:1619615]
ChEMBL	Inhibition of adenylate cyclase via adenosine A1 receptors in rat fat cell membranes	F	5.36	pIC50	4380	nM	IC50	J Med Chem (1992) 35: 2363-2368 [PMID:1619615]
ChEMBL	Functional activity against adenosine A1 receptor from rat atria.	F	5	pEC50	>10000	nM	EC50	J Med Chem (1995) 38: 1462-1472 [PMID:7739005]
ChEMBL	Negative chronotropic activity via A1 Adenosine receptor was tested in spontaneously beating rat atria	F	5	pEC50	>10000	nM	EC50	J Med Chem (1994) 37: 1720-1726 [PMID:8201607]
ChEMBL	Adenosine A1 receptor mediated negative chronotropic activity in spontaneously beating rat atria	F	9	pEC50	>1	nM	EC50	J Med Chem (1996) 39: 4211-4217 [PMID:8863798]
A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274]
GtoPdb	-	-	8.3	pKi	-	-	-	J Med Chem (2002) 45: 3271-9 [PMID:12109910]; Biochem Pharmacol (1999) 57: 65-75 [PMID:9920286]; Br J Pharmacol (1997) 121: 353-60 [PMID:9179373]
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
ChEMBL	Displacement of [3H]-CGS- 51680 from Adenosine A2A receptor of rat striatum.	B	8.66	pKi	2.2	nM	Ki	J Med Chem (1996) 39: 4211-4217 [PMID:8863798]
ChEMBL	Binding affinity against adenosine A2a receptor from rat striatum using [3H]-CGS- 21680 as a radioligand.	B	8.66	pKi	2.2	nM	Ki	J Med Chem (1995) 38: 1462-1472 [PMID:7739005]
ChEMBL	Binding affinity to adenosine A2A receptor in rat striatal membranes by measuring displacement of specific [3H]-CGS- 21680 as radioligand	B	8.66	pKi	2.2	nM	Ki	J Med Chem (1995) 38: 1174-1188 [PMID:7707320]
ChEMBL	Vasorelaxation as Adenosine A2A receptor activity in rat aorta	F	6.22	pEC50	596	nM	EC50	J Med Chem (1996) 39: 4211-4217 [PMID:8863798]
ChEMBL	Functional activity against adenosine A2a receptor from rat aorta.	F	6.22	pEC50	596	nM	EC50	J Med Chem (1995) 38: 1462-1472 [PMID:7739005]
A3 receptor in Human [GtoPdb: 21] [UniProtKB: P0DMS8]
GtoPdb	-	-	8.6	pKi	-	-	-	J Med Chem (2002) 45: 3271-9 [PMID:12109910]
A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647]
ChEMBL	Binding affinity determined by displacement of specific binding of [125I]N-(4-amino-3-iodophenethyl)-adenosine in membranes of CHO cells stably transfected with the rat adenosine A3 receptor	B	7.59	pKi	25.6	nM	Ki	J Med Chem (1995) 38: 1174-1188 [PMID:7707320]
A2B receptor in Human [GtoPdb: 20] [UniProtKB: P29275]
GtoPdb	-	-	6.6	pKi	-	-	-	Biochem Pharmacol (2005) 70: 1601-12 [PMID:16219300]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]