5S-HETE [Ligand Id: 3390] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL164813
  • 5-LOX/Arachidonate 5-lipoxygenase in Human [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
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  • OXE receptor in Human [GtoPdb: 271] [UniProtKB: Q8TDS5]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
ChEMBL Inhibitory activity against 5-lipoxygenase B 5.7 pIC50 2000 nM IC50 J. Med. Chem. (1983) 26: 72-78 [PMID:6298421]
OXE receptor in Human [GtoPdb: 271] [UniProtKB: Q8TDS5]
GtoPdb - - 7.2 pEC50 60 nM EC50 Biochim Biophys Acta (1994) 1201: 505-15 [PMID:7803484];
J Biol Chem (1993) 268: 9280-6 [PMID:8387490];
Biochem Biophys Res Commun (2005) 334: 987-95 [PMID:16039985]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]