CP105696 [Ligand Id: 3368] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL51770 (CP-105696) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| BLT1 receptor/Leukotriene B4 receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722] | ||||||||
| ChEMBL | Tested for antagonistic activity against LTB4 receptor in guinea pig spleen membrane | F | 8.01 | pIC50 | 9.7 | nM | IC50 | J Med Chem (1994) 37: 3197-3199 [PMID:7932545] |
| ChEMBL | Compound was tested for inhibitory activity against Leukotriene B4 receptor binding | B | 8.08 | pIC50 | 8.4 | nM | IC50 | J Med Chem (1996) 39: 2629-2654 [PMID:8709092] |
| GtoPdb | - | - | 8.1 | pIC50 | 8.42 | nM | IC50 | J Pharmacol Exp Ther (1995) 273: 176-84 [PMID:7714764] |
| ChEMBL | Tested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibition | B | 8.25 | pIC50 | 5.6 | nM | IC50 | J Med Chem (1994) 37: 3197-3199 [PMID:7932545] |
| BLT1 receptor/Leukotriene B4 receptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2657] [GtoPdb: 267] [UniProtKB: O88855] | ||||||||
| ChEMBL | Tested for antagonistic activity in mouse spleen membrane against LTB4 receptor | F | 7.52 | pIC50 | 30.3 | nM | IC50 | J Med Chem (1994) 37: 3197-3199 [PMID:7932545] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
