coenzyme A [Ligand Id: 3044] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1213327 (CoASH, Coenzyme A)
  • choline O-acetyltransferase/Choline acetylase in Human [ChEMBL: CHEMBL4039] [GtoPdb: 2480] [UniProtKB: P28329]
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  • lysine acetyltransferase 5/Histone acetyltransferase KAT5 in Human [ChEMBL: CHEMBL5750] [GtoPdb: 2664] [UniProtKB: Q92993]
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  • E1A binding protein p300/Histone acetyltransferase p300 in Human [ChEMBL: CHEMBL3784] [GtoPdb: 2735] [UniProtKB: Q09472]
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  • lysine acetyltransferase 2B/Histone acetyltransferase PCAF in Human [ChEMBL: CHEMBL5500] [GtoPdb: 2737] [UniProtKB: Q92831]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
choline O-acetyltransferase/Choline acetylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4039] [GtoPdb: 2480] [UniProtKB: P28329]
ChEMBL Inhibition of choline acetyltransferase isolated from squid head ganglia B 4.12 pKi 75000 nM Ki J. Med. Chem. (1981) 24: 1534-1537 [PMID:7310833]
lysine acetyltransferase 5/Histone acetyltransferase KAT5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5750] [GtoPdb: 2664] [UniProtKB: Q92993]
ChEMBL Inhibition of recombinant Tip60 (1-513) expressed in Escherichia coli BL21 (DE3) by liquid scintillation B 4.08 pIC50 82270 nM IC50 Bioorg. Med. Chem. (2009) 17: 1381-1386 [PMID:19114310]
E1A binding protein p300/Histone acetyltransferase p300 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3784] [GtoPdb: 2735] [UniProtKB: Q09472]
ChEMBL Inhibition of recombinant p300 B 4.34 pIC50 45940 nM IC50 Bioorg. Med. Chem. (2009) 17: 1381-1386 [PMID:19114310]
lysine acetyltransferase 2B/Histone acetyltransferase PCAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5500] [GtoPdb: 2737] [UniProtKB: Q92831]
ChEMBL Inhibition of PCAF HAT domain (493-658) expressed in Escherichia coli BL21 (DE3) B 4.38 pIC50 41910 nM IC50 Bioorg. Med. Chem. (2009) 17: 1381-1386 [PMID:19114310]

ChEMBL data shown on this page come from version 25:

A.P. Bento, A. Gaulton, A. Hersey, et al. (2014). The ChEMBL bioactivity database: an update. Nucl. Acids Res. Database Issue. 42 D1083-D1090. [PMID:24214965]