coenzyme A [Ligand Id: 3044] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1213327 (CoASH, Coenzyme_a, Coenzyme A)
  • choline O-acetyltransferase/Choline acetylase in Human [ChEMBL: CHEMBL4039] [GtoPdb: 2480] [UniProtKB: P28329]
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  • lysine acetyltransferase 5/Histone acetyltransferase KAT5 in Human [ChEMBL: CHEMBL5750] [GtoPdb: 2664] [UniProtKB: Q92993]
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  • E1A binding protein p300/Histone acetyltransferase p300 in Human [ChEMBL: CHEMBL3784] [GtoPdb: 2735] [UniProtKB: Q09472]
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  • lysine acetyltransferase 2B/Histone acetyltransferase PCAF in Human [ChEMBL: CHEMBL5500] [GtoPdb: 2737] [UniProtKB: Q92831]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
choline O-acetyltransferase/Choline acetylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4039] [GtoPdb: 2480] [UniProtKB: P28329]
ChEMBL Inhibition of choline acetyltransferase isolated from squid head ganglia B 4.12 pKi 75000 nM Ki J Med Chem (1981) 24: 1534-1537 [PMID:7310833]
lysine acetyltransferase 5/Histone acetyltransferase KAT5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5750] [GtoPdb: 2664] [UniProtKB: Q92993]
ChEMBL Inhibition of recombinant Tip60 (1-513) expressed in Escherichia coli BL21 (DE3) by liquid scintillation B 4.08 pIC50 82270 nM IC50 Bioorg Med Chem (2009) 17: 1381-1386 [PMID:19114310]
E1A binding protein p300/Histone acetyltransferase p300 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3784] [GtoPdb: 2735] [UniProtKB: Q09472]
ChEMBL Inhibition of recombinant p300 B 4.34 pIC50 45940 nM IC50 Bioorg Med Chem (2009) 17: 1381-1386 [PMID:19114310]
lysine acetyltransferase 2B/Histone acetyltransferase PCAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5500] [GtoPdb: 2737] [UniProtKB: Q92831]
ChEMBL Inhibition of PCAF HAT domain (493-658) expressed in Escherichia coli BL21 (DE3) B 4.38 pIC50 41910 nM IC50 Bioorg Med Chem (2009) 17: 1381-1386 [PMID:19114310]
N-alpha-acetyltransferase 50 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630854] [UniProtKB: Q9GZZ1]
ChEMBL Binding affinity to full length human N-terminal His-tagged/GST-tagged Naa50 expressed in Escherichia coli BL21(DE3) cells in by SPR analysis B 6.81 pKd 156 nM Kd ACS Med Chem Lett (2020) 11: 1175-1184 [PMID:32550998]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]