Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL1213327 (CoASH, Coenzyme_a, Coenzyme A) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
choline O-acetyltransferase/Choline acetylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4039] [GtoPdb: 2480] [UniProtKB: P28329] | ||||||||
ChEMBL | Inhibition of choline acetyltransferase isolated from squid head ganglia | B | 4.12 | pKi | 75000 | nM | Ki | J Med Chem (1981) 24: 1534-1537 [PMID:7310833] |
lysine acetyltransferase 5/Histone acetyltransferase KAT5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5750] [GtoPdb: 2664] [UniProtKB: Q92993] | ||||||||
ChEMBL | Inhibition of recombinant Tip60 (1-513) expressed in Escherichia coli BL21 (DE3) by liquid scintillation | B | 4.08 | pIC50 | 82270 | nM | IC50 | Bioorg Med Chem (2009) 17: 1381-1386 [PMID:19114310] |
E1A binding protein p300/Histone acetyltransferase p300 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3784] [GtoPdb: 2735] [UniProtKB: Q09472] | ||||||||
ChEMBL | Inhibition of recombinant p300 | B | 4.34 | pIC50 | 45940 | nM | IC50 | Bioorg Med Chem (2009) 17: 1381-1386 [PMID:19114310] |
lysine acetyltransferase 2B/Histone acetyltransferase PCAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5500] [GtoPdb: 2737] [UniProtKB: Q92831] | ||||||||
ChEMBL | Inhibition of PCAF HAT domain (493-658) expressed in Escherichia coli BL21 (DE3) | B | 4.38 | pIC50 | 41910 | nM | IC50 | Bioorg Med Chem (2009) 17: 1381-1386 [PMID:19114310] |
N-alpha-acetyltransferase 50 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630854] [UniProtKB: Q9GZZ1] | ||||||||
ChEMBL | Binding affinity to full length human N-terminal His-tagged/GST-tagged Naa50 expressed in Escherichia coli BL21(DE3) cells in by SPR analysis | B | 6.81 | pKd | 156 | nM | Kd | ACS Med Chem Lett (2020) 11: 1175-1184 [PMID:32550998] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]