pentylthio-TZTP [Ligand Id: 304] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL130715
  • M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
  • M1 receptor/Muscarinic acetylcholine receptor M1 in Rat [ChEMBL: CHEMBL276] [GtoPdb: 13] [UniProtKB: P08482]
  • This target only has 1 pki data point
  • 0
1 CHEMBL130715_lig_chart_1 M1 receptor HumanRat
There should be some charts here, you may need to enable JavaScript!
  • M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
  • This target only has 1 pki data point
  • 7.9
2 CHEMBL130715_lig_chart_2 M2 receptor Human
There should be some charts here, you may need to enable JavaScript!
  • M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
  • This target only has 1 pki data point
  • 8.1
3 CHEMBL130715_lig_chart_3 M3 receptor Human
There should be some charts here, you may need to enable JavaScript!
  • M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
  • This target only has 1 pki data point
  • 8.7
4 CHEMBL130715_lig_chart_4 M4 receptor Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
M1 receptor in Human [GtoPdb: 13] [UniProtKB: P11229]
GtoPdb - - 8.6 pKi - - - Mol Pharmacol (1997) 52: 172-9 [PMID:9224827]
M1 receptor/Muscarinic acetylcholine receptor M1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL276] [GtoPdb: 13] [UniProtKB: P08482]
ChEMBL Displacement of [3H]oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1 B 8.32 pIC50 4.8 nM IC50 J. Med. Chem. (1992) 35: 4011-4019 [PMID:1433209]
ChEMBL Displacement of [3H]pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1 B 8.62 pIC50 2.4 nM IC50 J. Med. Chem. (1992) 35: 4011-4019 [PMID:1433209]
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 7.9 pKi - - - Mol Pharmacol (1997) 52: 172-9 [PMID:9224827]
M3 receptor in Human [GtoPdb: 15] [UniProtKB: P20309]
GtoPdb - - 8.1 pKi - - - Mol Pharmacol (1997) 52: 172-9 [PMID:9224827]
M4 receptor in Human [GtoPdb: 16] [UniProtKB: P08173]
GtoPdb - - 8.7 pKi - - - Mol Pharmacol (1997) 52: 172-9 [PMID:9224827]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]