VPC44116 [Ligand Id: 2930] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL389033
  • S1P1 receptor/Sphingosine 1-phosphate receptor Edg-1 in Human [ChEMBL: CHEMBL4333] [GtoPdb: 275] [UniProtKB: P21453]
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  • S1P3 receptor/Sphingosine 1-phosphate receptor Edg-3 in Human [ChEMBL: CHEMBL3892] [GtoPdb: 277] [UniProtKB: Q99500]
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  • S1P4 receptor/Sphingosine 1-phosphate receptor Edg-6 in Human [ChEMBL: CHEMBL3230] [GtoPdb: 278] [UniProtKB: O95977]
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  • S1P5 receptor/Sphingosine 1-phosphate receptor Edg-8 in Human [ChEMBL: CHEMBL2274] [GtoPdb: 279] [UniProtKB: Q9H228]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
S1P1 receptor/Sphingosine 1-phosphate receptor Edg-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4333] [GtoPdb: 275] [UniProtKB: P21453]
ChEMBL Displacement of [32P]S1P from human S1P1 receptor expressed in HEK293T cells B 7.52 pKi 30 nM Ki Bioorg Med Chem (2007) 15: 663-677 [PMID:17113298]
GtoPdb - - 8.52 pKi 3 nM Ki Bioorg Med Chem (2007) 15: 663-77 [PMID:17113298]
GtoPdb - - 7.57 pIC50 - - - Bioorg Med Chem (2007) 15: 663-77 [PMID:17113298]
S1P3 receptor/Sphingosine 1-phosphate receptor Edg-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3892] [GtoPdb: 277] [UniProtKB: Q99500]
GtoPdb - - 6.52 pKi 300 nM Ki Bioorg Med Chem (2007) 15: 663-77 [PMID:17113298]
ChEMBL Displacement of [32P]S1P from human S1P3 receptor expressed in HEK293T cells B 6.52 pKi 300 nM Ki Bioorg Med Chem (2007) 15: 663-677 [PMID:17113298]
S1P4 receptor/Sphingosine 1-phosphate receptor Edg-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3230] [GtoPdb: 278] [UniProtKB: O95977]
ChEMBL Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay F 5.21 pEC50 6100 nM EC50 Bioorg Med Chem (2007) 15: 663-677 [PMID:17113298]
S1P5 receptor/Sphingosine 1-phosphate receptor Edg-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2274] [GtoPdb: 279] [UniProtKB: Q9H228]
ChEMBL Activity at human S1P5 receptor expressed in HEK293T cells by [35S]GTP-gamma-S binding assay F 7.48 pEC50 33 nM EC50 Bioorg Med Chem (2007) 15: 663-677 [PMID:17113298]
GtoPdb - - 7.5 pEC50 - - - Bioorg Med Chem (2007) 15: 663-77 [PMID:17113298]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]