tetrodotoxin [Ligand Id: 2616] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Nav1.1 in Rat [GtoPdb: 578] [UniProtKB: P04774] | ||||||||
| GtoPdb | - | - | 8 | pKd | - | - | - | J Neurosci (1998) 18: 811-20 [PMID:9437003] |
| Nav1.2 in Rat [GtoPdb: 579] [UniProtKB: P04775] | ||||||||
| GtoPdb | - | - | 8 | pIC50 | 11.2 | nM | IC50 | Nature (2005) 434: 763-7 [PMID:15815630] |
| Nav1.3 in Human [GtoPdb: 580] [UniProtKB: Q9NY46] | ||||||||
| GtoPdb | - | - | 8.4 | pIC50 | 4 | nM | IC50 | Eur J Neurosci (2000) 12: 4281-9 [PMID:11122339] |
| Nav1.4 in Human [GtoPdb: 581] [UniProtKB: P35499] | ||||||||
| GtoPdb | - | - | 7.6 | pIC50 | 25 | nM | IC50 | Pflugers Arch (1994) 427: 136-42 [PMID:8058462] |
| Nav1.4 in Rat [GtoPdb: 581] [UniProtKB: P15390] | ||||||||
| GtoPdb | - | - | 8.3 | pIC50 | - | - | - | Neuron (1989) 3: 33-49 [PMID:2559760] |
| Nav1.5 in Rat [GtoPdb: 582] [UniProtKB: P15389] | ||||||||
| GtoPdb | - | - | 5.8 | pKd | 1520 | nM | Kd |
Am J Physiol (1996) 270: C1522-31 [PMID:8967455]; FEBS Lett (1990) 275: 195-200 [PMID:2175715] |
| Nav1.6 in Mouse [GtoPdb: 583] [UniProtKB: Q9WTU3] | ||||||||
| GtoPdb | - | - | 8.2 | pIC50 | - | - | - | J Neurosci (1998) 18: 6093-102 [PMID:9698304] |
| Nav1.6 in Rat [GtoPdb: 583] [UniProtKB: O88420] | ||||||||
| GtoPdb | - | - | 9 | pIC50 | 1 | nM | IC50 | J Neurochem (1998) 70: 2262-72 [PMID:9603190] |
| Nav1.7 in Human [GtoPdb: 584] [UniProtKB: Q15858] | ||||||||
| GtoPdb | - | - | 7.6 | pIC50 | 24.5 | nM | IC50 | EMBO J (1995) 14: 1084-90 [PMID:7720699] |
| Nav1.7 in Rat [GtoPdb: 584] [UniProtKB: O08562] | ||||||||
| GtoPdb | - | - | 8.4 | pIC50 | - | - | - | J Biol Chem (1997) 272: 14805-9 [PMID:9169448] |
| Nav1.8 in Rat [GtoPdb: 585] [UniProtKB: Q62968] | ||||||||
| GtoPdb | - | - | 4.2 | pIC50 | 59600 | nM | IC50 | Nature (1996) 379: 257-62 [PMID:8538791] |
| Nav1.9 in Rat [GtoPdb: 586] [UniProtKB: O88457] | ||||||||
| GtoPdb | - | - | 4.4 | pIC50 | 39000 | nM | IC50 | J Neurosci (1999) 19: RC43 [PMID:10594087] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
