adenosine 5'-monophosphate [Ligand Id: 2455] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL752 (5'-adenylic acid, A 5MP, A-5MP, Adenosine 5'-monophosphoric acid, Adenosine Monophosphate, Adenosine phosphate, Adenyl, My-b-den, NSC-20264, Vitamin b8) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 2`-deoxynucleoside 5`-phosphate N-hydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3351218] [UniProtKB: O43598] | ||||||||
| ChEMBL | Inhibition of human DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometrically | B | 4.72 | pKi | 19200 | nM | Ki | Eur J Med Chem (2014) 85: 418-437 [PMID:25108359] |
| 2`-deoxynucleoside 5`-phosphate N-hydrolase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3329079] [UniProtKB: O35820] | ||||||||
| ChEMBL | Inhibition of rat DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometrically | B | 4.4 | pKi | 40000 | nM | Ki | Eur J Med Chem (2014) 85: 418-437 [PMID:25108359] |
| A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
| ChEMBL | Agonist activity at human A1AR expressed in HEK293T/17 cells assessed as inhibition of isoproterenol-induced cAMP accumulation incubated for 10 mins by luciferase reporter assay | F | 6.3 | pEC50 | 500 | nM | EC50 | J Med Chem (2012) 55: 6467-6477 [PMID:22738238] |
| Adenylate kinase 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2376] [UniProtKB: P29410] | ||||||||
| ChEMBL | Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP | B | 4.1 | pKi | 80000 | nM | Ki | J Med Chem (1982) 25: 1179-1184 [PMID:6292418] |
| protein kinase AMP-activated non-catalytic subunit beta 2/protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 2/protein kinase AMP-activated catalytic subunit alpha 1/protein kinase AMP-activated non-catalytic subunit gamma 3/protein kinase AMP-activated non-catalytic subunit gamma 2/protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase, AMPK in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2096907] [GtoPdb: 1544, 1545, 1542, 1541, 1547, 1546, 1543] [UniProtKB: O43741, P54619, P54646, Q13131, Q9UGI9, Q9UGJ0, Q9Y478] | ||||||||
| ChEMBL | Activation of human AMPK after 15 mins | B | 5.23 | pEC50 | 5900 | nM | EC50 | ACS Med Chem Lett (2010) 1: 478-482 [PMID:24900234] |
| protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 1/protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111345] [GtoPdb: 1545, 1541, 1543] [UniProtKB: P54619, Q13131, Q9Y478] | ||||||||
| ChEMBL | Binding affinity to recombinant human AMPK alpha1/beta1/gamma1 by SPR binding assay | B | 5.43 | pKd | 3700 | nM | Kd | J Med Chem (2016) 59: 8068-8081 [PMID:27490827] |
| ChEMBL | Activation of recombinant human AMPK alpha1/beta1/gamma1 using Cy5-labelled SAMS as substrate assessed as protection from Thr172 residue dephosphorylation preincubated for 15 mins followed by incubation with PP2a for 60 mins measured 60 mins post okadaic acid/Cy5-labelled SAMS and ATP addition by TR-FRET assay | B | 5.82 | pEC50 | 1519 | nM | EC50 | J Med Chem (2016) 59: 8068-8081 [PMID:27490827] |
| protein kinase AMP-activated non-catalytic subunit gamma 1/protein kinase AMP-activated catalytic subunit alpha 2/protein kinase AMP-activated non-catalytic subunit beta 1/AMPK alpha2/beta1/gamma1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038455] [GtoPdb: 1545, 1542, 1543] [UniProtKB: P54619, P54646, Q9Y478] | ||||||||
| ChEMBL | Allosteric activation of AMPK alpha2/beta1/gamma1 in human HepG2 cells by scintillation proximity assay | B | 5.85 | pEC50 | 1400 | nM | EC50 | Bioorg Med Chem Lett (2020) 30: 126790-126790 [PMID:31744674] |
| Fructose-1,6-bisphosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3975] [UniProtKB: P09467] | ||||||||
| ChEMBL | Inhibition of human liver fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphoglucose isomerase/glucose-6-phosphate dehydrogenase coupled assay | B | 5.01 | pIC50 | 9800 | nM | IC50 | Eur J Med Chem (2010) 45: 1478-1484 [PMID:20116906] |
| ChEMBL | Inhibition of human liver FBPase expressed in Escherichia coli BL21(DE3) using FBP as substrate in presence of PGI and G6PDH by spectrophotometric method | B | 5.48 | pIC50 | 3300 | nM | IC50 | J Med Chem (2020) 63: 10307-10329 [PMID:32820629] |
| ChEMBL | Inhibition of human recombinant FBPase expressed in Escherichia coli BL21(DE3) by phosphoglucose isomerase and glucose-6-phosphate dehydrogenase coupled assay | B | 5.49 | pIC50 | 3200 | nM | IC50 | Bioorg Med Chem (2014) 22: 1850-1862 [PMID:24530031] |
| ChEMBL | Inhibition of human liver FBPase expressed in Escherichia coli BL21(DE3) Rosetta cells assessed as reduction of NADP+ to NADPH by phosphoglucose isomerase and glucose-6-phosphate dehydrogenase coupling based spectrophotometry | B | 5.49 | pIC50 | 3200 | nM | IC50 | Eur J Med Chem (2015) 90: 394-405 [PMID:25461330] |
| ChEMBL | Inhibition of human liver FBP1 incubated for 5 mins by fluorescence method | B | 5.59 | pIC50 | 2600 | nM | IC50 | J Nat Prod (2020) 83: 1541-1552 [PMID:32364726] |
| ChEMBL | Inhibition of wild-type full-length human liver FBPase expressed in Escherichia coli BL21 (DE3) using FBP as substrate by malachite green dye based assay | B | 5.64 | pIC50 | 2300 | nM | IC50 | Eur J Med Chem (2020) 203: 112500-112500 [PMID:32711108] |
| ChEMBL | Inhibition of human FBPase expressed in Escherichia coli BL21 (DE3) using FBP as substrate incubated for 5 mins by malachite green dye based spectrophotometry | B | 5.64 | pIC50 | 2300 | nM | IC50 | Eur J Med Chem (2019) 184: 111749-111749 [PMID:31589992] |
| ChEMBL | Inhibition of FBPase (unknown origin) | B | 6 | pIC50 | 1000 | nM | IC50 | Medchemcomm (2011) 2: 287-290 |
| ChEMBL | Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometry | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2009) 52: 2880-2898 [PMID:19348494] |
| ChEMBL | Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase. | B | 6.1 | pIC50 | 800 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 17-21 [PMID:11140724] |
| ChEMBL | Inhibition of FBPase in human liver | B | 6.36 | pIC50 | 440 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 594-599 [PMID:19969452] |
| ChEMBL | Inhibition of FBPase in human liver using fructose-2,6phosphate as a substrate | B | 6.85 | pIC50 | 140 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 594-599 [PMID:19969452] |
| Fructose-1,6-bisphosphatase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2263] [UniProtKB: P00636] | ||||||||
| ChEMBL | Inhibition of pig FBPase expressed in Escherichia coli EK1601 by spectrophotometry | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem (2009) 17: 3916-3922 [PMID:19419876] |
| ChEMBL | Inhibition of pig kidney fructose-1,6-bisphosphatase expressed in Escherichia coli BL21 (DE3) assessed as reduction of NADP+ to NADPH by phosphoglucose isomerase/glucose-6-phosphate dehydrogenase coupled assay | B | 5.89 | pIC50 | 1300 | nM | IC50 | Eur J Med Chem (2010) 45: 1478-1484 [PMID:20116906] |
| Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL243] [UniProtKB: Q72874] | ||||||||
| ChEMBL | Equilibrium constant for the interaction between inhibitor and HIV-1 Protease | B | 8.95 | pKd | 1.13 | nM | Kd | J Med Chem (2002) 45: 5430-5439 [PMID:12459011] |
| ChEMBL | Inhibition constant against HIV-1 Protease | B | 9.64 | pKi | 0.23 | nM | Ki | J Med Chem (2002) 45: 5430-5439 [PMID:12459011] |
| P2Y purinoceptor 1 in Turkey (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5720] [UniProtKB: P49652] | ||||||||
| ChEMBL | Measure of Agonist Potency at turkey Purinoceptor P2Y1 stably expressed in 131N1 astrocytoma cell | F | 5.46 | pEC50 | 3500 | nM | EC50 | J Med Chem (2002) 45: 208-218 [PMID:11754592] |
| ChEMBL | Measure of Agonist Potency at turkey Purinoceptor P2Y1 stably expressed in 131N1 astrocytoma cell | F | 5.55 | pEC50 | 2800 | nM | EC50 | J Med Chem (2002) 45: 208-218 [PMID:11754592] |
| P2Y1 receptor/Purinergic receptor P2Y1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4315] [GtoPdb: 323] [UniProtKB: P47900] | ||||||||
| ChEMBL | Measure of Agonist Potency at human P2Y purinoceptor 1 (hP2Y1) stably expressed in 131N1 astrocytoma cell | F | 5.14 | pEC50 | 7200 | nM | EC50 | J Med Chem (2002) 45: 208-218 [PMID:11754592] |
| ChEMBL | Measure of Agonist Potency at human P2Y purinoceptor 1 (hP2Y1) stably expressed in 131N1 astrocytoma cell | F | 5.82 | pEC50 | 1500 | nM | EC50 | J Med Chem (2002) 45: 208-218 [PMID:11754592] |
| P2Y11 receptor/Purinergic receptor P2Y11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4867] [GtoPdb: 327] [UniProtKB: Q96G91] | ||||||||
| ChEMBL | Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uM | F | 4.76 | pEC50 | 17250 | nM | EC50 | J Med Chem (2002) 45: 208-218 [PMID:11754592] |
| P2Y2 receptor/Purinergic receptor P2Y2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4398] [GtoPdb: 324] [UniProtKB: P41231] | ||||||||
| ChEMBL | Measure of Agonist Potency at human P2Y purinoceptor 2 (hP2Y2) stably expressed in 131N1 astrocytoma cell | F | 5.43 | pEC50 | 3700 | nM | EC50 | J Med Chem (2002) 45: 208-218 [PMID:11754592] |
| ChEMBL | Measure of Agonist Potency at human P2Y purinoceptor 2 (hP2Y2) stably expressed in 131N1 astrocytoma cell | F | 7.07 | pEC50 | 85 | nM | EC50 | J Med Chem (2002) 45: 208-218 [PMID:11754592] |
| TRPM2/Transient receptor potential cation channel subfamily M member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250402] [GtoPdb: 494] [UniProtKB: O94759] | ||||||||
| ChEMBL | Inhibition of TRPM2 (unknown origin) | B | 4.15 | pIC50 | 70000 | nM | IC50 | J Med Chem (2013) 56: 10079-10102 [PMID:24304219] |
| ChEMBL | Inhibition of human TRPM2 assessed as reduction in ADPR-induced channel currents by whole cell patch clamp electrophysiology method | B | 4.15 | pIC50 | 70000 | nM | IC50 | Eur J Med Chem (2018) 152: 235-252 [PMID:29723786] |
| SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
| ChEMBL | Inhibition of p60c-src expressed in chick embryo fibroblast | B | 7 | pIC50 | 100 | nM | IC50 | J Nat Prod (1992) 55: 1529-1560 [PMID:1479375] |
| TRPM4 in Human [GtoPdb: 496] [UniProtKB: Q8TD43] | ||||||||
| GtoPdb | - | - | 4.7 | pIC50 | - | - | - | Pflugers Arch (2004) 448: 70-5 [PMID:14758478] |
| AMP kinase in Human [GtoPdb: 1540] | ||||||||
| GtoPdb | Activation of AMPK partially purified from HEK cells. | - | 4.21 | pEC50 | 61000 | nM | EC50 | Cell Metab (2006) 3: 403-16 [PMID:16753576] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
