cyclic GMP [Ligand Id: 2347] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL395336 (cyclic GMP)
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  • CNGA1 in Human [GtoPdb: 394] [UniProtKB: P29973]
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  • CNGA2 in Rat [GtoPdb: 395] [UniProtKB: Q00195]
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  • CNGA3 in Human [GtoPdb: 396] [UniProtKB: Q16281]
  • CNGA3 in Rat [GtoPdb: 396]
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  • HCN2 in Mouse [GtoPdb: 401] [UniProtKB: O88703]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Phosphodiesterase 3B in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5129] [UniProtKB: E1BN64]
ChEMBL Inhibition of bovine arterial Phosphodiesterase 3 B 7 pIC50 100 nM IC50 J Med Chem (1996) 39: 297-303 [PMID:8568820]
CNGA1 in Human [GtoPdb: 394] [UniProtKB: P29973]
GtoPdb - - 4.22 pKi 60000 nM Ki Neuron (2002) 36: 891-6 [PMID:12467592];
Neuron (1995) 14: 177-83 [PMID:7530019];
J Neurosci (1992) 12: 3248-56 [PMID:1379636];
Proc Natl Acad Sci USA (1995) 92: 10177-81 [PMID:7479749];
Biophys J (1998) 74: 1333-45 [PMID:9512030];
Proc Natl Acad Sci USA (1994) 91: 11757-61 [PMID:7526403];
J Gen Physiol (1999) 113: 17-34 [PMID:9874685]
CNGA2 in Rat [GtoPdb: 395] [UniProtKB: Q00195]
GtoPdb - - 5.76 pEC50 1740 nM EC50 Neuron (1994) 13: 611-21 [PMID:7522482];
Proc Natl Acad Sci USA (1994) 91: 8890-4 [PMID:7522325];
Sci Signal (2012) 5: ra48 [PMID:22786723]
CNGA3 in Human [GtoPdb: 396] [UniProtKB: Q16281]
GtoPdb - - 5.6 pKd - - - FEBS Lett (1996) 393: 211-5 [PMID:8814292];
Eur J Neurosci (1997) 9: 2512-21 [PMID:9517456];
J Biol Chem (2003) 278: 24617-23 [PMID:12730238]
CNGA3 in Rat [GtoPdb: 396]
GtoPdb - - 5.51 pKd - - - J Neurophysiol (2001) 85: 2335-49 [PMID:11387380]
HCN2 in Mouse [GtoPdb: 401] [UniProtKB: O88703]
GtoPdb - - 5.2 pKi - - - Nature (1998) 393: 587-91 [PMID:9634236]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]