NS309 [Ligand Id: 2317] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL499968 (NS-309) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3780] [GtoPdb: 383] [UniProtKB: P70605] | ||||||||
| ChEMBL | Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells | B | 4.3 | pKi | >50000 | nM | Ki | J Med Chem (2008) 51: 7625-7634 [PMID:18998663] |
| KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1] | ||||||||
| GtoPdb | - | - | 6.2 | pEC50 | - | - | - |
Biochim Biophys Acta (2004) 1665: 1-5 [PMID:15471565]; J Biol Chem (2005) 280: 41404-11 [PMID:16239218]; Prog Neurobiol (2010) 91: 242-55 [PMID:20359520] |
| KCa3.1 in Human [GtoPdb: 384] [UniProtKB: O15554] | ||||||||
| GtoPdb | - | - | 8 | pEC50 | - | - | - |
Biochim Biophys Acta (2004) 1665: 1-5 [PMID:15471565]; Prog Neurobiol (2010) 91: 242-55 [PMID:20359520] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
