ChEMBL ligand: CHEMBL499968 (NS-309)
KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Rat [ChEMBL: CHEMBL3780] [GtoPdb: 383] [UniProtKB: P70605] There should be some charts here, you may need to enable JavaScript!
KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1] There should be some charts here, you may need to enable JavaScript!
KCa3.1 in Human [GtoPdb: 384] [UniProtKB: O15554] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3780] [GtoPdb: 383] [UniProtKB: P70605]
ChEMBL	Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells	B	4.3	pKi	>50000	nM	Ki	J Med Chem (2008) 51: 7625-7634 [PMID:18998663]
KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1]
GtoPdb	-	-	6.2	pEC50	-	-	-	Biochim Biophys Acta (2004) 1665: 1-5 [PMID:15471565]; J Biol Chem (2005) 280: 41404-11 [PMID:16239218]; Prog Neurobiol (2010) 91: 242-55 [PMID:20359520]
KCa3.1 in Human [GtoPdb: 384] [UniProtKB: O15554]
GtoPdb	-	-	8	pEC50	-	-	-	Biochim Biophys Acta (2004) 1665: 1-5 [PMID:15471565]; Prog Neurobiol (2010) 91: 242-55 [PMID:20359520]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]