WAY-163909 [Ligand Id: 229] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1628670 (WAY-163909)
  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL Binding affinity to 5HT2C receptor (unknown origin) B 7.98 pKi 10.5 nM Ki Bioorg Med Chem Lett (2020) 30: 126929-126929 [PMID:31952960]
GtoPdb - - 8 pKi 10 nM Ki J Pharmacol Exp Ther (2005) 313: 862-9 [PMID:15705738]
ChEMBL Displacement of [125I]DOI from human 5-HT2C receptor B 8 pKi 10 nM Ki J. Med. Chem. (2014) 57: 1488-1494 [PMID:24491146]
ChEMBL Agonist activity at human 5-HT2C receptor assessed as stimulation of Ca2+ mobilization F 8.1 pEC50 8 nM EC50 J. Med. Chem. (2014) 57: 1488-1494 [PMID:24491146]
ChEMBL Agonist activity at 5HT2C receptor (unknown origin) relative to control B 8.1 pEC50 8 nM EC50 J. Med. Chem. (2015) 58: 1992-2002 [PMID:25633969]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]