WAY-163909 [Ligand Id: 229] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1628670 (WAY-163909) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | Binding affinity to 5HT2C receptor (unknown origin) | B | 7.98 | pKi | 10.5 | nM | Ki | Bioorg Med Chem Lett (2020) 30: 126929-126929 [PMID:31952960] |
| GtoPdb | - | - | 8 | pKi | 10 | nM | Ki | J Pharmacol Exp Ther (2005) 313: 862-9 [PMID:15705738] |
| ChEMBL | Displacement of [125I]DOI from human 5-HT2C receptor | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2014) 57: 1488-1494 [PMID:24491146] |
| ChEMBL | Agonist activity at human 5-HT2C receptor assessed as stimulation of Ca2+ mobilization | F | 8.1 | pEC50 | 8 | nM | EC50 | J Med Chem (2014) 57: 1488-1494 [PMID:24491146] |
| ChEMBL | Agonist activity at 5HT2C receptor (unknown origin) relative to control | B | 8.1 | pEC50 | 8 | nM | EC50 | J Med Chem (2015) 58: 1992-2002 [PMID:25633969] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
