Ro 25-1553 [Ligand Id: 2259] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| PAC1 receptor in Human [GtoPdb: 370] [UniProtKB: P41586] | ||||||||
| GtoPdb | inhibition of [125I]-PACAP-27 binding to membranes from NIH/3T3 cells stably expressing the recombinant receptor | - | 6 | pIC50 | >1000 | nM | IC50 | J Mol Neurosci (2002) 18: 29-35 [PMID:11931347] |
| GtoPdb | stimulation of cyclic AMP formation in NIH/3T3 cells stably expressing the recombinant receptor | - | 6 | pEC50 | >1000 | nM | EC50 | J Mol Neurosci (2002) 18: 29-35 [PMID:11931347] |
| PAC1 receptor in Rat [GtoPdb: 370] [UniProtKB: P32215] | ||||||||
| GtoPdb | inhibition of [125I]-[Ac-His1]PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor | - | 5 | pIC50 | >10000 | nM | IC50 | Peptides (1997) 18: 403-8 [PMID:9145428] |
| VPAC1 receptor in Human [GtoPdb: 371] [UniProtKB: P32241] | ||||||||
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 6 | pIC50 | >1000 | nM | IC50 | J Mol Neurosci (2002) 18: 29-35 [PMID:11931347] |
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 6.1 | pIC50 | 800 | nM | IC50 | Mol Pharmacol (1999) 56: 1280-7 [PMID:10570056] |
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 7 | pIC50 | 100 | nM | IC50 | Peptides (1997) 18: 403-8 [PMID:9145428] |
| GtoPdb | cyclic AMP formation in CHO cells stably expressing recombinant receptor | - | 6 | pEC50 | 1000 | nM | EC50 | Mol Pharmacol (1999) 56: 1280-7 [PMID:10570056] |
| GtoPdb | stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor | - | 6 | pEC50 | >1000 | nM | EC50 | J Mol Neurosci (2002) 18: 29-35 [PMID:11931347] |
| VPAC2 receptor in Human [GtoPdb: 372] [UniProtKB: P41587] | ||||||||
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 9.52 | pIC50 | 0.3 | nM | IC50 |
J Mol Neurosci (2002) 18: 29-35 [PMID:11931347]; Mol Pharmacol (1999) 56: 1280-7 [PMID:10570056]; Peptides (1997) 18: 403-8 [PMID:9145428] |
| GtoPdb | cyclic AMP formation in CHO cells stably expressing recombinant receptor | - | 8.3 | pEC50 | 5 | nM | EC50 | Mol Pharmacol (1999) 56: 1280-7 [PMID:10570056] |
| GtoPdb | stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor | - | 8.7 | pEC50 | 2 | nM | EC50 | J Mol Neurosci (2002) 18: 29-35 [PMID:11931347] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
