latanoprost (free acid form) [Ligand Id: 1960] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1050 (Latanoprost acid, Latonoprost acid) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| FP receptor in Human [GtoPdb: 344] [UniProtKB: P43088] | ||||||||
| GtoPdb | - | - | 8.6 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
| Prostanoid FP receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4820] [UniProtKB: P37289] | ||||||||
| ChEMBL | Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane | B | 7.01 | pKi | 98 | nM | Ki | Bioorg Med Chem (2009) 17: 576-584 [PMID:19101156] |
| FP receptor/Prostanoid FP receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5000] [GtoPdb: 344] [UniProtKB: P43117] | ||||||||
| ChEMBL | Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting | F | 7.5 | pEC50 | 31.7 | nM | EC50 | Bioorg Med Chem (2009) 17: 576-584 [PMID:19101156] |
| ChEMBL | Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR | F | 8.2 | pEC50 | 6.31 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 939-943 [PMID:23317571] |
| OATP2A1/Solute carrier organic anion transporter family member 2A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073703] [GtoPdb: 1223] [UniProtKB: Q92959] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of PGE1 uptake (PGE1: 0.0004 uM) in PGT-expressing HeLa cells | F | 6.83 | pKi | 149 | nM | Ki | Exp Eye Res (2002) 74: 41-49 [PMID:11878817] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
