AH6809 [Ligand Id: 1896] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1317823
  • DP1 receptor/Prostanoid DP receptor in Human [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258]
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  • EP1 receptor/Prostanoid EP1 receptor in Human [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
  • EP1 receptor in Rat [GtoPdb: 340] [UniProtKB: P70597]
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  • EP2 receptor/Prostanoid EP2 receptor in Human [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
  • EP2 receptor in Mouse [GtoPdb: 341] [UniProtKB: Q62053]
  • EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928]
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  • EP3 receptor/Prostanoid EP3 receptor in Human [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
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  • EP4 receptor/Prostanoid EP4 receptor in Human [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
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  • IP receptor/Prostanoid IP receptor in Human [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
DP1 receptor/Prostanoid DP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258]
GtoPdb - - 5.8 pKi - - - Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]
ChEMBL Antagonist activity at DP1 receptor (unknown origin) by functional cAMP assay F 5.85 pKi 1400 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995]
ChEMBL Antagonist activity at EP1 receptor (unknown origin) by functional cAMP assay F 5.92 pKi 1200 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
GtoPdb - - 6 pKi - - - Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944];
J Pharm Pharmacol (2002) 54: 539-47 [PMID:11999132]
EP1 receptor in Rat [GtoPdb: 340] [UniProtKB: P70597]
GtoPdb - - 5.9 pKi - - - Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116]
GtoPdb - - 5.9 pKi - - - Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]
ChEMBL Antagonist activity at EP2 receptor (unknown origin) by functional cAMP assay F 5.94 pKi 1150 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
ChEMBL Inhibition of EP2 receptor (unknown origin) by competitive binding assay B 5.94 pKi 1150 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
EP2 receptor in Mouse [GtoPdb: 341] [UniProtKB: Q62053]
GtoPdb - - 6.5 pKi - - - Br J Pharmacol (1997) 122: 217-24 [PMID:9313928]
EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928]
GtoPdb - - 6.3 pKi - - - Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820]
EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115]
ChEMBL Antagonist activity at EP3 receptor (unknown origin) by functional cAMP assay F 5.8 pKi 1600 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
GtoPdb - - 5.8 pKi 1600 nM Ki Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]
EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408]
ChEMBL Antagonist activity at EP4 receptor (unknown origin) by functional cAMP assay F 4 pKi >100000 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]
IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
ChEMBL Antagonist activity at prostanoid IP receptor (unknown origin) by functional cAMP assay F 4 pKi >100000 nM Ki J Med Chem (2014) 57: 4454-4465 [PMID:24279689]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]