L-888,291 [Ligand Id: 1880] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL264421
  • TP receptor/Thromboxane A2 receptor in Human [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
Created with Highcharts 10.3.3ValuesChart context menuThromboxane A2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258]
Created with Highcharts 10.3.3ValuesChart context menuDP1 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • DP2 receptor in Human [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
Created with Highcharts 10.3.3ValuesChart context menuDP2 receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731]
ChEMBL Binding affinity to human recombinant TP receptor by radioligand competition binding assay B 7.77 pKi 17 nM Ki Bioorg Med Chem Lett (2008) 18: 2696-2700 [PMID:18359630]
DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258]
GtoPdb - - 7.4 pKi - - - Mol Pharmacol (2005) 67: 1834-9 [PMID:15755909]
DP2 receptor in Human [GtoPdb: 339] [UniProtKB: Q9Y5Y4]
GtoPdb - - 7.32 pKi 48 nM Ki Mol Pharmacol (2005) 67: 1834-9 [PMID:15755909]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]