adenosine-3'-5'-bisphosphate [Ligand Id: 1718] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL574817 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| P2Y purinoceptor 1 in Turkey (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5720] [UniProtKB: P49652] | ||||||||
| ChEMBL | In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes. | F | 4.83 | pIC50 | 14900 | nM | IC50 | J Med Chem (1999) 42: 1625-1638 [PMID:10229631] |
| ChEMBL | Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATP | F | 5.38 | pIC50 | 4190 | nM | IC50 | J Med Chem (1998) 41: 183-190 [PMID:9457242] |
| ChEMBL | Concentration at which 50% of the maximal effect (stimulation of PLC at P2Y1 receptor in the turkey erythrocyte membranes) is reached | F | 5.63 | pEC50 | 2340 | nM | EC50 | J Med Chem (1999) 42: 1625-1638 [PMID:10229631] |
| ChEMBL | Agonist activity at P2Y1 receptor measured as capacity to stimulate 50% phospholipase C in turkey erythrocyte membranes | F | 5.89 | pEC50 | 1280 | nM | EC50 | J Med Chem (1998) 41: 183-190 [PMID:9457242] |
| P2Y1 receptor in Human [GtoPdb: 323] [UniProtKB: P47900] | ||||||||
| GtoPdb | - | - | 5.6 | pEC50 | - | - | - | Mol Pharmacol (1996) 50: 1323-9 [PMID:8913364] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
