ChEMBL ligand: CHEMBL2088034 (Ro-646198)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
NOP receptor/Nociceptin receptor in Human [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter	B	6.4	pKi	>400	nM	Ki	J. Med. Chem. (2012) 55: 4955-4967 [PMID:22541041]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter	B	6.4	pKi	>400	nM	Ki	J. Med. Chem. (2012) 55: 4955-4967 [PMID:22541041]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter	B	6.4	pKi	>400	nM	Ki	J. Med. Chem. (2012) 55: 4955-4967 [PMID:22541041]
NOP receptor/Nociceptin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146]
ChEMBL	Displacement of [3H]Nociceptin from human recombinant NOP receptor expressed in CHO cells by scintillation counter	B	8.95	pKi	1.12	nM	Ki	J. Med. Chem. (2012) 55: 4955-4967 [PMID:22541041]
GtoPdb	-	-	9.41	pKi	-	-	-	Proc Natl Acad Sci USA (2000) 97: 4938-43 [PMID:10758169]; Eur J Med Chem (2000) 35: 839-51 [PMID:11006485]
GtoPdb	Stimulation of GTPγ35S binding	-	7.41	pEC50	-	-	-	Eur J Med Chem (2000) 35: 839-51 [PMID:11006485]
ChEMBL	Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay	F	7.68	pEC50	21	nM	EC50	J. Med. Chem. (2012) 55: 4955-4967 [PMID:22541041]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]