ChEMBL ligand: CHEMBL381055
caseinolytic mitochondrial matrix peptidase proteolytic subunit/ATP-dependent Clp protease proteolytic subunit, mitochondrial in Human [ChEMBL: CHEMBL4523305] [GtoPdb: 3273] [UniProtKB: Q16740] There should be some charts here, you may need to enable JavaScript!
mGlu5 receptor/Metabotropic glutamate receptor 5 in Human [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594] mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
caseinolytic mitochondrial matrix peptidase proteolytic subunit/ATP-dependent Clp protease proteolytic subunit, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523305] [GtoPdb: 3273] [UniProtKB: Q16740]
ChEMBL	Agonist activity at N-terminal SUMO tagged human ClpP transfected in Escherichia coli assessed as induction of alpha-casein degradation preincubated for 10 mins followed by alpha-casein addition and measured after 2 hrs by brilliant blue staining based SDS-PAGE analysis	B	4.53	pEC50	29710	nM	EC50	J Med Chem (2024) 67: 10622-10642 [PMID:38905539]
ChEMBL	Agonist activity at human ClpP using Ac-WLA-AMC as substrate assessed as induction of substrate degradation	B	5.92	pEC50	1200	nM	EC50	J Med Chem (2024) 67: 10622-10642 [PMID:38905539]
mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594]
ChEMBL	Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assay	F	6.7	pEC50	199.53	nM	EC50	J Med Chem (2013) 56: 7243-7259 [PMID:23947773]
ChEMBL	Positive allosteric modulation of human mGluR5a transfected in HEK293 cells by calcium mobilization assay	F	6.7	pEC50	199	nM	EC50	J Med Chem (2013) 56: 7243-7259 [PMID:23947773]
GtoPdb	-	-	6.8	pEC50	157	nM	EC50	Neuropharmacology (2013) 64: 224-39 [PMID:22884720]
ChEMBL	Positive allosteric modulation of human mGluR5 stably expressed in HEK293 cells assessed as Ca2+ flux by FLIPR assay	F	6.8	pEC50	157	nM	EC50	J Med Chem (2013) 56: 7976-7996 [PMID:24050755]
mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424]
GtoPdb	-	-	5.44	pKi	3650	nM	Ki	Neuropharmacology (2013) 64: 224-39 [PMID:22884720]
GtoPdb	-	-	6.5	pIC50	-	-	-	Neuropharmacology (2005) 49 (S1): 252-
ChEMBL	Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes	F	6.77	pEC50	170	nM	EC50	J Med Chem (2006) 49: 3332-3344 [PMID:16722652]
ChEMBL	Positive allosteric modulation of rat mGluR5 stably expressed in HEK293 cells assessed as Ca2+ flux by FLIPR assay	F	7.26	pEC50	55	nM	EC50	J Med Chem (2013) 56: 7976-7996 [PMID:24050755]
GtoPdb	-	-	7.26	pEC50	55	nM	EC50	Neuropharmacology (2013) 64: 224-39 [PMID:22884720]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]