MGS0028 [Ligand Id: 1395] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL121053 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu2 receptor/Metabotropic glutamate receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5137] [GtoPdb: 290] [UniProtKB: Q14416] | ||||||||
| ChEMBL | Agonist activity at mGLUR2 expressed in CHO cells | F | 9.24 | pEC50 | 0.57 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 1958-1962 [PMID:22318160] |
| mGlu2 receptor/Metabotropic glutamate receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2851] [GtoPdb: 290] [UniProtKB: P31421] | ||||||||
| ChEMBL | Tested for binding affinity against Metabotropic glutamate receptor 2 in CHO cells using [3H]-7 as radioligand | B | 8.48 | pKi | 3.3 | nM | Ki | J Med Chem (2000) 43: 4893-4909 [PMID:11123999] |
| GtoPdb | - | - | 9.2 | pKi | - | - | - | J Med Chem (2000) 43: 4893-909 [PMID:11123999] |
| ChEMBL | Antagonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated in presence of 30 uM glutamic acid | F | 4 | pEC50 | >100000 | nM | EC50 | J Med Chem (2000) 43: 4893-4909 [PMID:11123999] |
| ChEMBL | Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formation | F | 7.02 | pEC50 | 94.7 | nM | EC50 | J Med Chem (2000) 43: 4893-4909 [PMID:11123999] |
| ChEMBL | Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formation | F | 8.9 | pEC50 | 1.26 | nM | EC50 | J Med Chem (2000) 43: 4893-4909 [PMID:11123999] |
| ChEMBL | Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formation | F | 9.24 | pEC50 | 0.57 | nM | EC50 | J Med Chem (2000) 43: 4893-4909 [PMID:11123999] |
| mGlu3 receptor/Metabotropic glutamate receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2888] [GtoPdb: 291] [UniProtKB: Q14832] | ||||||||
| ChEMBL | Agonist activity at mGLUR3 expressed in CHO cells | F | 8.68 | pEC50 | 2.07 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 1958-1962 [PMID:22318160] |
| mGlu3 receptor/Metabotropic glutamate receptor 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3067] [GtoPdb: 291] [UniProtKB: P31422] | ||||||||
| ChEMBL | Tested for binding affinity against Metabotropic glutamate receptor 3 in CHO cells using [3H]-7 as radioligand | B | 8.44 | pKi | 3.62 | nM | Ki | J Med Chem (2000) 43: 4893-4909 [PMID:11123999] |
| ChEMBL | Antagonist activity against Metabotropic glutamate receptor 3 expressed in CHO cells was evaluated in presence of 30 uM glutamic acid | F | 4 | pEC50 | >100000 | nM | EC50 | J Med Chem (2000) 43: 4893-4909 [PMID:11123999] |
| ChEMBL | Agonist potency against cloned Metabotropic glutamate receptor 3 | F | 8.68 | pEC50 | 2.07 | nM | EC50 | J Med Chem (2000) 43: 4893-4909 [PMID:11123999] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
