emupertinib [Ligand Id: 13742] activity data from GtoPdb

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  • epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533]
Created with Highcharts 10.3.3ValuesChart context menuepidermal growth factor receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533]
GtoPdb Inhibition of WT EGFR kinase activity - 9.04 pIC50 0.92 nM IC50 WO2020166680A1. 7h-pyrrolo[2,3-d]pyrimidine-4-amine derivative (2020)
GtoPdb Inhibition of EGFR (L858R/C797S) kinase activity - 9.16 pIC50 0.69 nM IC50 WO2020166680A1. 7h-pyrrolo[2,3-d]pyrimidine-4-amine derivative (2020)
GtoPdb Inhibition of EGFR (L858R/T790M/C797S) kinase activity - 9.28 pIC50 0.52 nM IC50 WO2020166680A1. 7h-pyrrolo[2,3-d]pyrimidine-4-amine derivative (2020)
GtoPdb Inhibition of EGFR (d746-750/T790M/C797S) kinase activity - 9.52 pIC50 <0.3 nM IC50 WO2020166680A1. 7h-pyrrolo[2,3-d]pyrimidine-4-amine derivative (2020)

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.