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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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epidermal growth factor receptor in Human [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
GtoPdb | Inhibition of WT EGFR kinase activity | - | 9.04 | pIC50 | 0.92 | nM | IC50 | WO2020166680A1. 7h-pyrrolo[2,3-d]pyrimidine-4-amine derivative (2020) |
GtoPdb | Inhibition of EGFR (L858R/C797S) kinase activity | - | 9.16 | pIC50 | 0.69 | nM | IC50 | WO2020166680A1. 7h-pyrrolo[2,3-d]pyrimidine-4-amine derivative (2020) |
GtoPdb | Inhibition of EGFR (L858R/T790M/C797S) kinase activity | - | 9.28 | pIC50 | 0.52 | nM | IC50 | WO2020166680A1. 7h-pyrrolo[2,3-d]pyrimidine-4-amine derivative (2020) |
GtoPdb | Inhibition of EGFR (d746-750/T790M/C797S) kinase activity | - | 9.52 | pIC50 | <0.3 | nM | IC50 | WO2020166680A1. 7h-pyrrolo[2,3-d]pyrimidine-4-amine derivative (2020) |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.