SNAP-7941 [Ligand Id: 1313] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL185271 (SNAP-7941) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] | ||||||||
| ChEMBL | Displacement of [125I]HEAT from human recombinant adrenergic alpha-1A receptor | B | 7.4 | pKi | 40 | nM | Ki | J Med Chem (2007) 50: 3883-3890 [PMID:17668922] |
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Displacement of [3H]spiperone from human recombinant dopamine D2 receptor | B | 5.55 | pKi | 2800 | nM | Ki | J Med Chem (2007) 50: 3883-3890 [PMID:17668922] |
| MCH1 receptor/Melanin-concentrating hormone receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL344] [GtoPdb: 280] [UniProtKB: Q99705] | ||||||||
| ChEMBL | Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay | F | 9.24 | pKd | 0.58 | nM | Kd | Bioorg Med Chem Lett (2009) 19: 6166-6171 [PMID:19773162] |
| GtoPdb | - | - | 9.7 | pKd | - | - | - | Nat Med (2002) 8: 825-830 [PMID:12118247] |
| ChEMBL | Concentration required to inhibit 50% of melanin-concentrating hormone induced [Ca2+] flux in IMR-32 cells measured by using a fluorometric imaging plate reader | F | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 4879-4882 [PMID:15341943] |
| ChEMBL | Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 4879-4882 [PMID:15341943] |
| GtoPdb | - | - | 9.2 | pA2 | - | - | - | Nat Med (2002) 8: 825-830 [PMID:12118247] |
| MCH1 receptor/Melanin-concentrating hormone receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075228] [GtoPdb: 280] [UniProtKB: P97639] | ||||||||
| ChEMBL | Binding affinity to rat MCH1 receptor | B | 8.7 | pKi | 2 | nM | Ki | J Med Chem (2004) 47: 6864-6874 [PMID:15615535] |
| ChEMBL | Displacement of [3H]SNAP 7941 from rat MCHR1 expressed in HEK293 cells | B | 9.6 | pKi | 0.25 | nM | Ki | J Med Chem (2007) 50: 3870-3882 [PMID:17668921] |
| ChEMBL | Displacement of [3H]T-226296 from rat recombinant MCH1 receptor | B | 9.6 | pKi | 0.25 | nM | Ki | J Med Chem (2007) 50: 3883-3890 [PMID:17668922] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
