bifemelane [Ligand Id: 11742] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1192517 (Bifemelane, Bifemelane hydrochloride, Bifemelano) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Lethal(3)malignant brain tumor-like protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287622] [UniProtKB: Q9Y468] | ||||||||
| ChEMBL | Inhibition of L3MBTL1 by alpha-screening | B | 4.04 | pIC50 | 91000 | nM | IC50 | J Med Chem (2010) 53: 7625-7631 [PMID:20931980] |
| Lethal(3)malignant brain tumor-like protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287624] [UniProtKB: Q8NA19] | ||||||||
| ChEMBL | Inhibition of L3MBTL4 by alpha-screening | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2010) 53: 7625-7631 [PMID:20931980] |
| MBT domain-containing protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287625] [UniProtKB: Q05BQ5] | ||||||||
| ChEMBL | Inhibition of MBTD1 by alpha-screening | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2010) 53: 7625-7631 [PMID:20931980] |
| Monoamine oxidase A in Human [GtoPdb: 2489] [UniProtKB: P21397] | ||||||||
| GtoPdb | Inhibition of monoamine oxidase (MAO) in human brain synaptosomes | - | 5.38 | pKi | 4200 | nM | Ki | J Neurochem (1988) 50: 243-7 [PMID:3335842] |
| Monoamine oxidase B in Human [GtoPdb: 2490] [UniProtKB: P27338] | ||||||||
| GtoPdb | - | - | 4.34 | pKi | 46000 | nM | Ki | J Neurochem (1988) 50: 243-7 [PMID:3335842] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
