bifemelane [Ligand Id: 11742] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1192517 (Bifemelane, Bifemelane hydrochloride) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Lethal(3)malignant brain tumor-like protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287622] [UniProtKB: Q9Y468] | ||||||||
| ChEMBL | Inhibition of L3MBTL1 by alpha-screening | B | 4.04 | pIC50 | 91000 | nM | IC50 | J Med Chem (2010) 53: 7625-7631 [PMID:20931980] |
| Lethal(3)malignant brain tumor-like protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287624] [UniProtKB: Q8NA19] | ||||||||
| ChEMBL | Inhibition of L3MBTL4 by alpha-screening | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2010) 53: 7625-7631 [PMID:20931980] |
| MBT domain-containing protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287625] [UniProtKB: Q05BQ5] | ||||||||
| ChEMBL | Inhibition of MBTD1 by alpha-screening | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2010) 53: 7625-7631 [PMID:20931980] |
| Monoamine oxidase A in Human [GtoPdb: 2489] [UniProtKB: P21397] | ||||||||
| GtoPdb | Inhibition of monoamine oxidase (MAO) in human brain synaptosomes | - | 5.38 | pKi | 4200 | nM | Ki | J Neurochem (1988) 50: 243-7 [PMID:3335842] |
| Monoamine oxidase B in Human [GtoPdb: 2490] [UniProtKB: P27338] | ||||||||
| GtoPdb | - | - | 4.34 | pKi | 46000 | nM | Ki | J Neurochem (1988) 50: 243-7 [PMID:3335842] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
