BAY-8400 [Ligand Id: 11732] activity data from GtoPdb

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  • ATM serine/threonine kinase in Human [GtoPdb: 1934] [UniProtKB: Q13315]
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  • ATR serine/threonine kinase in Human [GtoPdb: 1935] [UniProtKB: Q13535]
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  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta in Human [GtoPdb: 2154] [UniProtKB: P42338]
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  • protein kinase, DNA-activated, catalytic subunit in Human [GtoPdb: 2800] [UniProtKB: P78527]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ATM serine/threonine kinase in Human [GtoPdb: 1934] [UniProtKB: Q13315]
GtoPdb - - 4.71 pIC50 19300 nM IC50 J Med Chem (2021) 64: 12723-12737 [PMID:34428039]
ATR serine/threonine kinase in Human [GtoPdb: 1935] [UniProtKB: Q13535]
GtoPdb - - 6.4 pIC50 394 nM IC50 J Med Chem (2021) 64: 12723-12737 [PMID:34428039]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta in Human [GtoPdb: 2154] [UniProtKB: P42338]
GtoPdb - - 6.93 pIC50 117 nM IC50 J Med Chem (2021) 64: 12723-12737 [PMID:34428039]
protein kinase, DNA-activated, catalytic subunit in Human [GtoPdb: 2800] [UniProtKB: P78527]
GtoPdb - - 7.09 pIC50 81 nM IC50 J Med Chem (2021) 64: 12723-12737 [PMID:34428039]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.