VIP [Ligand Id: 1152] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| secretin receptor in Human [GtoPdb: 252] [UniProtKB: P47872] | ||||||||
| GtoPdb | - | - | 5.4 | pIC50 | - | - | - | EMBO J (1991) 10: 1635-41 [PMID:1646711] |
| secretin receptor in Rat [GtoPdb: 252] [UniProtKB: P23811] | ||||||||
| GtoPdb | Inhibition of [125I]Tyr25 secretin binding in membranes from CHO cells expressing recombinant receptor | - | 6.2 | pIC50 | 600 | nM | IC50 | Peptides (1997) 18: 1539-45 [PMID:9437714] |
| PAC1 receptor in Human [GtoPdb: 370] [UniProtKB: P41586] | ||||||||
| GtoPdb | inhibition of [125I]-PACAP-27 binding to membranes from HEK293 cells stably expressing the PAC1 very short receptor | - | 6 | pKi | >1000 | nM | Ki | J Neuroendocrinol (1999) 11: 941-9 [PMID:10583729] |
| GtoPdb | inhibition of [125I]-PACAP-27 binding to membranes from HEK293 cells stably expressing the full length receptor (ENST00000304166) | - | 6.3 | pKi | 458 | nM | Ki | J Neuroendocrinol (1999) 11: 941-9 [PMID:10583729] |
| GtoPdb | inhibition of [125I]-PACAP-27 binding to membranes from HEK293 cells stably expressing the PAC1 short receptor (ENST00000409363) | - | 8.4 | pKi | 4.4 | nM | Ki | J Neuroendocrinol (1999) 11: 941-9 [PMID:10583729] |
| GtoPdb | inhibition of [125I]-PACAP-27 binding to membranes from NIH/3T3 cells stably expressing the recombinant receptor | - | 6 | pIC50 | >1000 | nM | IC50 | J Mol Neurosci (2002) 18: 29-35 [PMID:11931347] |
| GtoPdb | stimulation of cyclic AMP formation in NIH/3T3 cells stably expressing the recombinant receptor | - | 6 | pEC50 | >1000 | nM | EC50 | J Mol Neurosci (2002) 18: 29-35 [PMID:11931347] |
| GtoPdb | stimulation of cyclic AMP formation in HEK293 cells stably expressing the PAC1 very short receptor | - | 6.4 | pEC50 | 373 | nM | EC50 | J Neuroendocrinol (1999) 11: 941-9 [PMID:10583729] |
| GtoPdb | calcium influx in CHO cells stably expressing recombinant receptor | - | 6.4 | pEC50 | 389 | nM | EC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
| GtoPdb | stimulation of cyclic AMP formation in HEK293 cells stably expressing the full length receptor (ENST00000304166) | - | 6.7 | pEC50 | 186 | nM | EC50 | J Neuroendocrinol (1999) 11: 941-9 [PMID:10583729] |
| GtoPdb | cyclic AMP formation in CHO cells stably expressing recombinant receptor | - | 7.8 | pEC50 | 15.1 | nM | EC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
| GtoPdb | stimulation of cyclic AMP formation in HEK293 cells stably expressing the PAC1 short receptor (ENST00000409363) | - | 8.7 | pEC50 | 2.1 | nM | EC50 | J Neuroendocrinol (1999) 11: 941-9 [PMID:10583729] |
| PAC1 receptor in Rat [GtoPdb: 370] [UniProtKB: P32215] | ||||||||
| GtoPdb | inhibition of [125I]-[Ac-His1]PACAP-27 binding to membranes from CHO cells stably expressing the rat PAC1 receptor isoform including the hop1 exon | - | 5.5 | pKi | 3500 | nM | Ki | Eur J Pharmacol (1995) 288: 259-67 [PMID:7774670] |
| GtoPdb | inhibition of [125I]-[Ac-His1]PACAP-27 binding to membranes from CHO cells stably expressing the rat PAC1 receptor isoform including the hop1 exon | - | 5.8 | pKi | 1500 | nM | Ki | Eur J Pharmacol (1995) 288: 259-67 [PMID:7774670] |
| GtoPdb | Inhibition of [125I]-Ac-His1-PACAP-27 binding in membranes from CHO cells expressing recombinant receptor | - | 5.7 | pIC50 | 2000 | nM | IC50 | Peptides (1997) 18: 1539-45 [PMID:9437714] |
| GtoPdb | stimulation of adenylate cyclase in CHO cells stably expressing the rat PAC1 receptor isoform including the hop1 exon | - | 7.1 | pEC50 | 80 | nM | EC50 | Eur J Pharmacol (1995) 288: 259-67 [PMID:7774670] |
| GtoPdb | stimulation of adenylate cyclase in CHO cells stably expressing the rat PAC1 receptor isoform lacking the hip and hop exons | - | 7.1 | pEC50 | 80 | nM | EC50 | Eur J Pharmacol (1995) 288: 259-67 [PMID:7774670] |
| VPAC1 receptor in Human [GtoPdb: 371] [UniProtKB: P32241] | ||||||||
| GtoPdb | inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor | - | 8.5 | pKi | 3.4 | nM | Ki | J Pharmacol Exp Ther (1997) 281: 629-33 [PMID:9152366] |
| GtoPdb | inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor | - | 8.9 | pKi | 1.4 | nM | Ki | J Pharmacol Exp Ther (1998) 284: 744-50 [PMID:9454823] |
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 9 | pKi | 0.9 | nM | Ki | J Biol Chem (2000) 275: 24003-12 [PMID:10801840] |
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 9 | pKi | 0.9 | nM | Ki | Eur J Pharmacol (1996) 302: 207-14 [PMID:8791009] |
| GtoPdb | inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor | - | 9.1 | pKi | 0.8 | nM | Ki | Biochem Biophys Res Commun (1993) 193: 546-553 [PMID:8390245] |
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 9.1 | pKi | 0.82 | nM | Ki | Biochem Biophys Res Commun (1994) 203: 141-8 [PMID:8074647] |
| GtoPdb | cyclic AMP formation in HEK293 cells stably expressing recombinant receptor | - | 9.7 | pKi | 0.2 | nM | Ki | Biochem Biophys Res Commun (1994) 203: 141-8 [PMID:8074647] |
| GtoPdb | cyclic AMP formation in CHO cells stably expressing recombinant receptor | - | 9.7 | pKi | 0.2 | nM | Ki | Biochem Biophys Res Commun (1994) 203: 141-8 [PMID:8074647] |
| GtoPdb | inhibition of [125I]-VIP binding to membranes from HEK293 cells stably expressing the recombinant receptor | - | 9.8 | pKi | 0.16 | nM | Ki | Biochem Biophys Res Commun (1994) 203: 141-8 [PMID:8074647] |
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 8 | pIC50 | 10 | nM | IC50 | J Mol Neurosci (2002) 18: 29-35 [PMID:11931347] |
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 8.7 | pIC50 | 2 | nM | IC50 | Eur J Pharmacol (1998) 354: 105-11 [PMID:9726637] |
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 8.7 | pIC50 | 2 | nM | IC50 | Ann N Y Acad Sci (1998) 865: 247-52 [PMID:9928018] |
| GtoPdb | Inhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptor | - | 8.7 | pIC50 | 2 | nM | IC50 | Peptides (1997) 18: 1539-45 [PMID:9437714] |
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 9.3 | pIC50 | 0.5 | nM | IC50 | Mol Pharmacol (1999) 56: 1280-7 [PMID:10570056] |
| GtoPdb | calcium influx in CHO cells stably expressing recombinant receptor | - | 7.9 | pEC50 | 14.1 | nM | EC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
| GtoPdb | stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor | - | 8.5 | pEC50 | 3 | nM | EC50 | J Mol Neurosci (2002) 18: 29-35 [PMID:11931347] |
| GtoPdb | stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor | - | 8.9 | pEC50 | 1.2 | nM | EC50 | J Pharmacol Exp Ther (1997) 281: 629-33 [PMID:9152366] |
| GtoPdb | cyclic AMP formation in CHO cells stably expressing recombinant receptor | - | 9.3 | pEC50 | 0.5 | nM | EC50 | Mol Pharmacol (1999) 56: 1280-7 [PMID:10570056] |
| GtoPdb | stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor | - | 9.4 | pEC50 | 0.4 | nM | EC50 | J Biol Chem (2000) 275: 24003-12 [PMID:10801840] |
| GtoPdb | cyclic AMP formation in CHO cells stably expressing recombinant receptor | - | 10 | pEC50 | 0.11 | nM | EC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
| VPAC1 receptor in Rat [GtoPdb: 371] [UniProtKB: P30083] | ||||||||
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 8.7 | pIC50 | 2 | nM | IC50 | Eur J Pharmacol (1998) 354: 105-11 [PMID:9726637] |
| GtoPdb | Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor | - | 8.7 | pIC50 | 2 | nM | IC50 | Peptides (1997) 18: 1539-45 [PMID:9437714] |
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 9 | pIC50 | 1 | nM | IC50 | Ann N Y Acad Sci (1998) 865: 247-52 [PMID:9928018] |
| VPAC2 receptor in Human [GtoPdb: 372] [UniProtKB: P41587] | ||||||||
| GtoPdb | inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor | - | 7.8 | pKi | 16 | nM | Ki | J Pharmacol Exp Ther (1997) 281: 629-33 [PMID:9152366] |
| GtoPdb | inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor | - | 8.7 | pKi | 1.8 | nM | Ki | J Pharmacol Exp Ther (1998) 284: 744-50 [PMID:9454823] |
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 8.8 | pKi | 1.7 | nM | Ki | J Biol Chem (2000) 275: 24003-12 [PMID:10801840] |
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 7.7 | pIC50 | 20 | nM | IC50 | J Mol Neurosci (2002) 18: 29-35 [PMID:11931347] |
| GtoPdb | inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor | - | 8 | pIC50 | 10 | nM | IC50 | Eur J Pharmacol (1998) 354: 105-11 [PMID:9726637] |
| GtoPdb | Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor | - | 8.3 | pIC50 | 5 | nM | IC50 | Peptides (1997) 18: 1539-45 [PMID:9437714] |
| GtoPdb | inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor | - | 8.5 | pIC50 | 3 | nM | IC50 | Ann N Y Acad Sci (1998) 865: 247-52 [PMID:9928018] |
| GtoPdb | inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor | - | 8.5 | pIC50 | 3 | nM | IC50 | Mol Pharmacol (1999) 56: 1280-7 [PMID:10570056] |
| GtoPdb | calcium influx in CHO cells stably expressing recombinant receptor | - | 7.3 | pEC50 | 50.9 | nM | EC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
| GtoPdb | cyclic AMP formation in CHO cells stably expressing recombinant receptor | - | 7.8 | pEC50 | 15 | nM | EC50 | Mol Pharmacol (1999) 56: 1280-7 [PMID:10570056] |
| GtoPdb | stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor | - | 7.9 | pEC50 | 14 | nM | EC50 | J Pharmacol Exp Ther (1997) 281: 629-33 [PMID:9152366] |
| GtoPdb | stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor | - | 8.5 | pEC50 | 3 | nM | EC50 | J Mol Neurosci (2002) 18: 29-35 [PMID:11931347] |
| GtoPdb | cyclic AMP formation in CHO cells stably expressing recombinant receptor | - | 9.2 | pEC50 | 0.63 | nM | EC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
| GtoPdb | stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor | - | 9.3 | pEC50 | 0.5 | nM | EC50 | J Biol Chem (2000) 275: 24003-12 [PMID:10801840] |
| VPAC2 receptor in Rat [GtoPdb: 372] [UniProtKB: P35000] | ||||||||
| GtoPdb | inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor | - | 8 | pIC50 | 10 | nM | IC50 | Eur J Pharmacol (1998) 354: 105-11 [PMID:9726637] |
| GtoPdb | inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor | - | 8.4 | pIC50 | 4 | nM | IC50 | Ann N Y Acad Sci (1998) 865: 247-52 [PMID:9928018] |
| GtoPdb | Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor | - | 8.4 | pIC50 | 4 | nM | IC50 | Peptides (1997) 18: 1539-45 [PMID:9437714] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
