GPI-1046 [Ligand Id: 11483] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL6367 (GPI-1046) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| FKBP prolyl isomerase 1A/FK506-binding protein 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1902] [GtoPdb: 2609] [UniProtKB: P62942] | ||||||||
| ChEMBL | Inhibitory activity against FK506 binding protein 12 | B | 8.12 | pKi | 7.5 | nM | Ki | J Med Chem (2002) 45: 3549-3557 [PMID:12139466] |
| ChEMBL | The compound was tested for binding affinity against rotamase | B | 8.12 | pKi | 7.5 | nM | Ki | J Med Chem (1998) 41: 3928-3939 [PMID:9767630] |
| ChEMBL | Ability to inhibit peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12 | B | 11 | pKi | 0.01 | nM | Ki | Bioorg Med Chem Lett (2002) 12: 1429-1433 [PMID:11992791] |
| ChEMBL | Binding affinity to FKBP12 by fluorescence polarization assay | B | 5.91 | pIC50 | 1240 | nM | IC50 | J Med Chem (2012) 55: 4114-4122 [PMID:22455444] |
| FKBP prolyl isomerase 1A/FK506-binding protein 1A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2095] [GtoPdb: 2609] [UniProtKB: Q62658] | ||||||||
| ChEMBL | In vitro inhibition of rotamase activity of FK506 binding protein 12 | B | 8.12 | pKi | 7.5 | nM | Ki | J Med Chem (2002) 45: 3558-3568 [PMID:12139467] |
| FKBP prolyl isomerase 4/FK506 binding protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4050] [GtoPdb: 3176] [UniProtKB: Q02790] | ||||||||
| ChEMBL | Binding affinity to FKBP52 FK1 domain by fluorescence polarization assay | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2012) 55: 4114-4122 [PMID:22455444] |
| FKBP prolyl isomerase 5/Peptidyl-prolyl cis-trans isomerase FKBP5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2052031] [GtoPdb: 3175] [UniProtKB: Q13451] | ||||||||
| ChEMBL | Binding affinity to FKBP51 FK1 domain by fluorescence polarization assay | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2012) 55: 4114-4122 [PMID:22455444] |
| mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345] | ||||||||
| ChEMBL | The inhibitory activity by using FK506 binding protein 12 SPA binding assay | B | 4.68 | pIC50 | 20892.96 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 1007-1010 [PMID:10843203] |
| FKBP prolyl isomerase 8 in Human [GtoPdb: 3177] [UniProtKB: Q14318] | ||||||||
| GtoPdb | - | - | 7.32 | pKi | 48 | nM | Ki | J Biol Chem (2006) 281: 14961-70 [PMID:16547004] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
